SYNTHESIS AND ANTI-HIV ACTIVITY OF DIFFERENT SUGAR-MODIFIED PYRIMIDINE AND PURINE NUCLEOSIDES

被引：138
作者：
HERDEWIJN, P [1 ]
BALZARINI, J [1 ]
BABA, M [1 ]
PAUWELS, R [1 ]
VANAERSCHOT, A [1 ]
JANSSEN, G [1 ]
DECLERCQ, E [1 ]
机构：
[1] CATHOLIC UNIV LEUVEN,REGA INST MED RES,MINDERBROEDERSSTR 10,B-3000 LOUVAIN,BELGIUM
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 1988年 / 31卷 / 10期
关键词：
D O I：
10.1021/jm00118a033
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
引用
收藏
页码：2040 / 2048
页数：9
相关论文
共 61 条
[1]   THE SYNTHESIS OF SOME BRANCHED-CHAIN-SUGAR NUCLEOSIDE ANALOGS [J].
ASHWELL, M ;
JONES, AS ;
WALKER, RT .
NUCLEIC ACIDS RESEARCH, 1987, 15 (05) :2157-2166
[2]   BOTH 2',3'-DIDEOXYTHYMIDINE AND ITS 2',3'-UNSATURATED DERIVATIVE (2',3'-DI-DEOXYTHYMIDINENE) ARE POTENT AND SELECTIVE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS-REPLICATION INVITRO [J].
BABA, M ;
PAUWELS, R ;
HERDEWIJN, P ;
DECLERCQ, E ;
DESMYTER, J ;
VANDEPUTTE, M .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 142 (01) :128-134
[3]   SELECTIVE-INHIBITION OF HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) BY 3'-AZIDO-2',3'-DIDEOXYGUANOSINE INVITRO [J].
BABA, M ;
PAUWELS, R ;
BALZARINI, J ;
HERDEWIJN, P ;
DECLERCQ, E .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 145 (03) :1080-1086
[4]   THE 2',3'-DIDEOXYRIBOSIDE OF 2,6-DIAMINOPURINE SELECTIVELY INHIBITS HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) REPLICATION INVITRO [J].
BALZARINI, J ;
PAUWELS, R ;
BABA, M ;
ROBINS, MJ ;
ZOU, R ;
HERDEWIJN, P ;
DECLERCQ, E .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 145 (01) :269-276
[5]  
BALZARINI J, 1987, MOL PHARMACOL, V32, P798
[6]   POTENT AND SELECTIVE ANTI-HTLV-III/LAV ACTIVITY OF 2',3'-DIDEOXYCYTIDINENE, THE 2',3'-UNSATURATED DERIVATIVE OF 2',3'-DIDEOXYCYTIDINE [J].
BALZARINI, J ;
PAUWELS, R ;
HERDEWIJN, P ;
DECLERCQ, E ;
COONEY, DA ;
KANG, GJ ;
DALAL, M ;
JOHNS, DG ;
BRODER, S .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986, 140 (02) :735-742
[7]  
BALZARINI J, 1988, MOL PHARMACOL, V33, P243
[8]   ANTI-RETROVIRUS ACTIVITY OF 3'-FLUORO-SUBSTITUTED AND 3'-AZIDO-SUBSTITUTED PYRIMIDINE 2',3'-DIDEOXYNUCLEOSIDE ANALOGS [J].
BALZARINI, J ;
BABA, M ;
PAUWELS, R ;
HERDEWIJN, P ;
DECLERCO, E .
BIOCHEMICAL PHARMACOLOGY, 1988, 37 (14) :2847-2856
[9]  
BALZARINI J, 1987, MOL PHARMACOL, V32, P162
[10]  
BALZARINI J, IN PRESS DEV MED VIR
1234567