Importance of Beta Cell Function for the Treatment of Type 2 Diabetes

被引：47

作者：

Saisho, Yoshifumi ^{[1
]}

机构：

[1] Keio Univ, Sch Med, Dept Internal Med, Shinjuku Ku, 35 Shinanomachi, Tokyo 1608582, Japan

来源：

JOURNAL OF CLINICAL MEDICINE | 2014年 / 3卷 / 03期

关键词：

type; 2; diabetes; beta cell; insulin secretion; therapy;

D O I：

10.3390/jcm3030923

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Type 2 diabetes (T2DM) is characterized by insulin resistance and beta cell dysfunction. Recent evidence has emerged that beta cell dysfunction is a common pathogenetic feature of both type 1 and type 2 diabetes, and T2DM never develops without beta cell dysfunction. Therefore, treatment of T2DM should aim to restore beta cell function. Although the treatment of T2DM has greatly improved over the past few decades, remaining issues in the current treatment of T2DM include (1) hypoglycemia; (2) body weight gain; (3) peripheral hyperinsulinemia and (4) postprandial hyperglycemia, which are all associated with inappropriate insulin supplementation, again underpinning the important role of endogenous and physiological insulin secretion in the management of T2DM. This review summarizes the current knowledge on beta cell function in T2DM and discusses the treatment strategy for T2DM in relation to beta cell dysfunction.

引用

页码：923 / 943

页数：21

共 126 条

[1] FDA places greater restrictions on access to rosiglitazone [J].

不详 .

BRITISH MEDICAL JOURNAL, 2010, 341

[2]

Apovian CM, 2013, AM J MANAG CARE, V19, pS219

[3] Efficacy of GLP-1 Receptor Agonists and DPP-4 Inhibitors: Meta-Analysis and Systematic Review [J].

Aroda, Vanita R. ;

Henry, Robert R. ;

Han, Jenny ;

Huang, Wenying ;

DeYoung, Mary Beth ;

Darsow, Tamara ;

Hoogwerf, Byron J. .

CLINICAL THERAPEUTICS, 2012, 34 (06) :1247-1258

[4] Effects of Metformin, Metformin Plus Rosiglitazone, and Metformin Plus Lifestyle on Insulin Sensitivity and β-cell Function in TODAY [J].

Arslanian, Silva ;

Pyle, Laura ;

Payan, Marisa ;

Bacha, Fida ;

Caprio, Sonia ;

Haymond, Morey W. ;

Levitsky, Lynne L. ;

Goland, Robin ;

White, Neil H. ;

Willi, Steven M. .

DIABETES CARE, 2013, 36 (06) :1749-1757

[5] Type 1 diabetes [J].

Atkinson, Mark A. ;

Eisenbarth, George S. ;

Michels, Aaron W. .

LANCET, 2014, 383 (9911) :69-82

[6] Accurate assessment of β-cell function -: The hyperbolic correction [J].

Bergman, RN ;

Ader, M ;

Huecking, K ;

Van Citters, G .

DIABETES, 2002, 51 :S212-S220

[7] Rosiglitazone: a European regulatory perspective [J].

Blind, E. ;

Dunder, K. ;

de Graeff, P. A. ;

Abadie, E. .

DIABETOLOGIA, 2011, 54 (02) :213-218

[8] C-peptide and the risk for incident complications and mortality in type 2 diabetic patients: a retrospective cohort study after a 14-year follow-up [J].

Bo, S. ;

Gentile, L. ;

Castiglione, A. ;

Prandi, V. ;

Canil, S. ;

Ghigo, E. ;

Ciccone, G. .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2012, 167 (02) :173-180

[9] Glucose tolerance and cardiovascular mortality -: Comparison of fasting and 2-hour diagnostic criteria [J].

Borch-Johnsen, K ;

Neil, A ;

Balkau, B ;

Larsen, S ;

Nissinen, A ;

Pekkanen, J ;

Tuomilehto, J ;

Jousilahti, P ;

Lindstrom, J ;

Pyörälä, M ;

Pyörälä, K ;

Eschwege, E ;

Gallus, G ;

Garancini, MP ;

Bouter, LM ;

Dekker, JM ;

Heine, RJ ;

Nijpels, HG ;

Stehouwer, CDA ;

Feskens, EJM ;

Kromhout, D ;

Peltonen, M ;

Pajak, A ;

Eriksson, J ;

Qiao, Q .

ARCHIVES OF INTERNAL MEDICINE, 2001, 161 (03) :397-405

[10] Intensive Lifestyle Intervention Reduces Urinary Incontinence in Overweight/Obese Men with Type 2 Diabetes: Results from the Look AHEAD Trial [J].

Breyer, Benjamin N. ;

Phelan, Suzanne ;

Hogan, Patricia E. ;

Rosen, Raymond C. ;

Kitabchi, Abbas E. ;

Wing, Rena R. ;

Brown, Jeanette S. .

JOURNAL OF UROLOGY, 2014, 192 (01) :144-149

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