CLINICAL IMPLICATION OF NEUROENDOCRINE DIFFERENTIATION IN PROSTATIC ADENOCARCINOMAS

被引：3
作者：
CONSTANTINIDES, C
PAVLAKI, K
ZIZI, D
GAVRIEL, J
MITROPOULOS, D
GARIFALOS, J
DIMOPOULOS, C
机构：
[1] Departments of Urology, Athens University Medical School
[2] Departments of Pathology, Athens University Medical School
[3] Department of Pathology, Tzanion Hospital, Piraeus
来源：
UROLOGIA INTERNATIONALIS | 1995年 / 55卷 / 03期
关键词：
PROSTATIC ADENOCARCINOMA; NEURON-SPECIFIC ENOLASE; NEUROENDOCRINE DIFFERENTIATION; IMMUNOHISTOCHEMISTRY;
D O I：
10.1159/000282769
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Specimens from 75 cases of prostatic adenocarcinoma of different M.D. Anderson degrees of malignancy were stained immunohistochemically for neuron-specific enolase (NSE), prostatic specific antigen (PSA) and prostatic acid phosphatase (PAP). None of these tumors presented on hematoxylin-eosin sections any features suggesting neuroendocrine differentiation; nevertheless, 18.7% of the tumors were at least focally NSE positive, Because of the synchronous antigenic expression of the NSE-positive cells to PSA and PAP, the authors suggest that prostatic exocrine and neuroendocrine cells derive from a common precursor stem cell. The possibility of a more aggressive biological behavior of these tumors in comparison to the conventional carcinomas is discussed. The probable clinical necessity for a combined therapeutic approach is also investigated.
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页码：134 / 136
页数：3
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