EFFECT OF A POTENT PAF ANTAGONIST, Y-24180, ON AN ALLERGEN-INDUCED LATE ASTHMATIC RESPONSE IN GUINEA-PIGS

被引：0

作者：

INOUE, H

ARATANI, H

TAKISHIMA, T

KAGOSHIMA, M

IWAHISA, Y

TERASAWA, M

机构：

[1] TOHOKU UNIV,SCH MED,DEPT INTERNAL MED 1,1-1 SEIRYO MACHI,AOBA KU,SENDAI,MIYAGI 980,JAPAN

[2] YOSHITOMI PHARMACEUT IND LTD,RES LABS,FUKUOKA 871,JAPAN

来源：

JOURNAL OF LIPID MEDIATORS | 1992年 / 5卷 / 02期

关键词：

PAF ANTAGONIST; Y-24180; LATE ASTHMATIC RESPONSE; BRONCHOALVEOLAR LAVAGE; ASCARIS-SUUM;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of Y-24180, a potent and specific PAF antagonist, on the antigen-induced late asthmatic response in guinea-pigs was investigated. We used an asthmatic guinea-pig model which had a high incidence of dual-phase reaction and high reproducibility. Y-24180 (1 mg/kg, p.o.) had a significant inhibitory effect on the late asthmatic response and eosinophil infiltration in bronchoalveolar lavage fluid. These results suggest that PAF may play, at least partially, an important role in the development of the late asthmatic response. Thus, Y-24180 may be useful for the treatment of asthma.

引用

页码：173 / 176

页数：4