THE SUBSTANCE-P RECEPTOR ANTAGONIST CP-96,345 INTERACTS WITH CA2+ CHANNELS

被引：112
|
作者：
SCHMIDT, AW [1 ]
MCLEAN, S [1 ]
HEYM, J [1 ]
机构：
[1] PFIZER INC,DEPT NEUROSCI,DIV CENT RES,GROTON,CT 06340
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 215卷 / 2-3期
关键词：
CP-96,345; SUBSTANCE P; CA2+ CHANNELS;
D O I：
10.1016/0014-2999(92)90057-B
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The nonpeptide substance P receptor antagonist CP-96,345 was found to displace binding to Ca2+ channel binding sites labelled with either [H-3]desmethoxyverapamil or [H-3]diltiazem and to enhance [H-3]nitrendipine binding. Unlike the substance P receptor antagonist activity of CP-96,345, these effects on Ca2+ channel binding sites were neither stereoselective nor species-dependent. It is concluded that CP-96,345 may act as an antagonist of L-type Ca2+ channels in addition to being a potent NK1 receptor (substance P) antagonist.
引用
收藏
页码：351 / 352
页数：2
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