EMBRYOTOXIC EVALUATION OF BIS (TRI-NORMAL-BUTYLTIN)OXIDE (TBTO) IN MICE

被引：12
作者：
BARONCELLI, S [1 ]
KARRER, D [1 ]
TURILLAZZI, PG [1 ]
机构：
[1] IST SUPER SANITA,TOSSICOL COMPARATA & ECOTOSSICOL LAB,VIA REGINA ELENA 299,I-00161 ROME,ITALY
来源：
TOXICOLOGY LETTERS | 1990年 / 50卷 / 2-3期
关键词：
Embryotoxicity; Maternal toxicity; Mouse; TBTO;
D O I：
10.1016/0378-4274(90)90018-H
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Pregnant mice were treated on days 6-15 of gestation with 5, 20 and 40 mg/kg/d bis (tri-n-butyltin)oxide (TBTO), and sacrificed on gestational day 17. At the highest dose TBTO caused a significant reduction of maternal body weight gain and also proved to be highly embryotoxic. Necropsy showed a dose-related decrease in spleen weight while a dose-dependent increase in placental weight was observed. © 1990.
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收藏
页码：257 / 262
页数：6
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