CHIRAL DISCRIMINATION OF PHENETHYLAMINES WITH BETA-CYCLODEXTRIN AND HEPTAKIS(2,3-DI-O-ACETYL)BETA-CYCLODEXTRIN BY CAPILLARY ELECTROPHORESIS AND NMR-SPECTROSCOPY

被引：50

作者：

BRANCH, SK ^{[1
]}

HOLZGRABE, U ^{[1
]}

JEFFERIES, TM ^{[1
]}

MALLWITZ, H ^{[1
]}

MATCHETT, MW ^{[1
]}

机构：

[1] UNIV BONN,INST PHARMAZEUT,D-53115 BONN,GERMANY

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1994年 / 12卷 / 12期

关键词：

CAPILLARY ELECTROPHORESIS; NMR SPECTROSCOPY; DERIVATIZED CYCLODEXTRINS; MODIFIED CYCLODEXTRINS; BETA-CYCLODEXTRIN; HEPTAKIS(2,3-DI-O-ACETYL)BETA-CYCLODEXTRIN; PHENETHYLAMINES;

D O I：

10.1016/0731-7085(94)00080-8

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The resolution of nine sympathomimetic phenethylamine racemates by beta-cyclodextrin and heptakis(2,3-di-O-acetyl)beta-cyclodextrin has been investigated by capillary electrophoresis and H-1 NMR spectroscopy. The NMR and capillary electrophoresis results showed that beta-cyclodextrin probably formed stronger complexes with the amines than did heptakis(2,3-di-O-acetyl)beta-cyclodextrin but was a poorer chiral discrimination agent in both techniques. The addition of heptakis(2,3-di-O-acetyl)beta-cyclodextrin to the capillary electrophoresis buffer gave baseline resolution of enantiomer peaks for seven of the compounds studied while beta-cyclodextrin resolved only three of the racemates.

引用

页码：1507 / 1517

页数：11

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