REGIOSELECTIVE AND CHEMOSELECTIVE SYNTHESIS OF HALOHYDRINS BY CLEAVAGE OF OXIRANES WITH METAL-HALIDES

被引：288

作者：

BONINI, C ^{[1
]}

RIGHI, G ^{[1
]}

机构：

[1] UNIV ROMA LA SAPIENZA,DIPARTIMENTO CHIM,CNR,CTR STUDIO CHIM SOSTANZE ORGAN NAT,I-00185 ROME,ITALY

来源：

SYNTHESIS-STUTTGART | 1994年 / 03期

关键词：

D O I：

10.1055/s-1994-25445

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Recent developments in the regio-, chemo- and stereoselective oxirane cleavage by new halogenating reagents allow obtention of various vicinal halohydrins. Also, epoxy alcohols and other functionalized oxiranes can be conveniently converted into the corresponding halohydrins. Some of the new methodologies have been successfully applied to the preparation of optically active fragments toward the synthesis to more complex molecules and natural products.

引用

页码：225 / 238

页数：14

共 99 条

[1] MILD AND STEREOCONTROLLED SYNTHESIS OF IODOHYDRINS AND BROMOHYDRINS BY X2-TI(O-ISO-PR)4 OPENING OF EPOXY ALCOHOLS [J].