ANTIHYPERGLYCEMIC EFFECT OF CHITOSAN OF PODOPHTHALMUS VIGIL IN STREPTOZOTOCIN INDUCED DIABETIC RATS

被引：5

作者：

Prabu, K. ^{[1
]}

Natarajan, E. ^{[1
]}

机构：

[1] Annamalai Univ, Fac Marine Sci, Ctr Adv Study Marine Biol, Parangipettai 608502, Tamil Nadu, India

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH | 2013年 / 4卷 / 01期

关键词：

Podophthalmus vigil; Antihyperglycaemia; Streptozotocin; Insulin; Carbohydrate metabolizing enzymes;

D O I：

10.13040/IJPSR.0975-8232.4(1).352-59

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The present study was designed to investigate the antihyperglycemic activity of chitosan of Podophthalmus vigil on normal and streptozotocin (STZ) diabetic rats. Diabetes was induced into male albino wistar rats by intraperitonial administration of STZ. Chitosan was administered orally at three different doses to normal and STZ-diabetic rats for 30 days. The diabetic rats showed an increase in levels of blood glucose and glycosylated hemoglobin (HbA1c) and a decrease in the levels of insulin and hemoglobin addition, diabetic rats showed a significant reduction in the activity of glucokinase and an elevation in the activities of gluconeogenic enzymes such as glucose-6-phosphatase and fructose-1, 6-bisphosphatase. Treatment with chitosan significantly decreased plasma glucose and HbA1c, and increased the insulin and Hb. Chitosan administration to diabetic rats reversed these enzyme activities in a significant manner. Thus, the results show that chitosan possesses an antihyperglycemic activity in the control of diabetes. The 300 mg dose of the extract produced a better effect than 100 and 200 mg doses.

引用

页码：352 / 359

页数：8

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