CHARACTERIZATION OF A SYNTHETIC PEPTIDE IMPURITY BY FAST-ATOM-BOMBARDMENT TANDEM MASS-SPECTROMETRY AND GAS-CHROMATOGRAPHY MASS-SPECTROMETRY

被引：6
作者：
BURINSKY, DJ
DUNPHY, R
OYLER, AR
SHAW, CJ
COTTER, ML
机构：
[1] R. W. Johnson Pharmaceutical Research Institute, Raritan, New Jersey, 08869-0602, Route 202
来源：
JOURNAL OF PHARMACEUTICAL SCIENCES | 1992年 / 81卷 / 06期
关键词：
D O I：
10.1002/jps.2600810627
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Fast-atom bombardment-tandem mass spectrometry (FAB-MS-MS) was used to characterize the structure of atosiban, a synthetic oxytocin antagonist, and one of its synthesis-related impurities. The nature of the structural modification in the impurity of interest, replacement of the proline residue by 5-aminovaleric acid, was determined directly from its product ion MS-MS spectrum. Confirmation of the identity of the impurity was accomplished with GC-MS.
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页码：597 / 600
页数：4
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