THYROID ABNORMALITIES DURING LITHIUM TREATMENT

被引：75

作者：

BOCCHETTA, A ^{[1
]}

BERNARDI, F ^{[1
]}

PEDDITZI, M ^{[1
]}

LOVISELLI, A ^{[1
]}

VELLUZZI, F ^{[1
]}

MARTINO, E ^{[1
]}

DELZOMPO, M ^{[1
]}

机构：

[1] UNIV CAGLIARI,INST INTERNAL MED,DEPT ENDOCRINOL,I-09124 CAGLIARI,ITALY

来源：

ACTA PSYCHIATRICA SCANDINAVICA | 1991年 / 83卷 / 03期

关键词：

LITHIUM; CARBAMAZEPINE; ANTITHYROID ANTIBODY; GOITER; HYPOTHYROIDISM; THYROID HORMONE;

D O I：

10.1111/j.1600-0447.1991.tb05523.x

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Thyroid function was evaluated in 150 Sardinian outpatients at different stages of lithium treatment. A visible and/or palpable goitre was found in 51% of patients, and there was no apparent correlation with the duration of treatment. No cases of symptomatic hypothyroidism were observed, but subclinical hypothyroidism was present in 19% of patients. The prevalence of specific antithyroid antibodies was positively correlated with age and duration of lithium treatment, and was higher in women. Subclinical hypothyroidism was observed in 53% of antibody-positive lithium-treated patients. Carbamazepine in combination with lithium was associated with significantly lower levels of total T4 and T3 than with lithium alone, and the ratios between total and free hormones were also decreased.

引用

页码：193 / 198

页数：6

共 45 条

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[2]

BAKKER K, 1982, Agressologie, V23, P89

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