Combination Therapy Efavirenz/Emtricitabine/Tenofovir Disoproxil Fumarate Associated with Hepatic Failure

被引：6

作者：

Qayyum, Sohail ^{[1
]}

Dong, Huijun ^{[2
]}

Kovacic, Dianne ^{[1
]}

Sohail, Sidra ^{[3
]}

Waters, Bradford ^{[4
]}

Thornton, Camille ^{[5
]}

Corbett, Cathy E. ^{[6
]}

机构：

[1] Univ Tennessee, Ctr Hlth Sci, Dept Pathol, Memphis, TN 38163 USA

[2] VA Med Ctr, Dept Pathol, Memphis, TN USA

[3] Rawalpindi Med Coll, Rawalpindi, Pakistan

[4] VA Med Ctr, Dept Gastroenterol, Memphis, TN USA

[5] MED, Memphis, TN USA

[6] VA Med Ctr, Dept Infect Dis, Memphis, TN USA

来源：

CURRENT DRUG SAFETY | 2012年 / 7卷 / 05期

关键词：

Drug induced hepatic failure; AIDS combination therapy;

D O I：

10.2174/157488612805076534

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A single pill daily fixed dose combination of Efavirenz, Emtricitabine, and Tenofovir Disoproxil Fumarate (EFV/FTC/TDF) provides a potent and convenient treatment option for HIV/AIDS. The components have been shown to be well tolerated and are effective in randomized controlled trials. A literature search revealed no case of hepatic failure reported with this drug combination. We here in describe the 1st case of acute hepatic failure developing after 3 months of treatment with EFV/FTC/TDF in a 41 year old African American male without pre-existing liver disease or risk factors.

引用

页码：391 / 393

页数：3

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