EPSTEIN-BARR-VIRUS DETECTION BY IN-SITU HYBRIDIZATION IN FINE-NEEDLE ASPIRATION BIOPSIES

被引:11
作者
PACCHIONI, D
NEGRO, F
VALENTE, G
BUSSOLATI, G
机构
[1] UNIV TURIN,DEPT BIOMED SCI & ONCOL,VIA SANTENA 7,I-10126 TURIN,ITALY
[2] OSPED MOLINETTE,DEPT GASTROENTEROL,TURIN,ITALY
关键词
IN-SITU HYBRIDIZATION; EPSTEIN-BARR VIRUS; UNDIFFERENTIATED NASOPHARYNGEAL CARCINOMA; FINE-NEEDLE ASPIRATION;
D O I
10.1097/00019606-199406000-00006
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Metastasis to neck lymph nodes is often the presenting symptom of occult head and neck tumors, including undifferentiated nasopharyngeal carcinoma (UNPC). The diagnosis of the primary site of the tumor by conventional cytological analysis of tissue obtained by fine-needle aspiration (FNA) may be difficult. As Epstein-Barr virus (EBV) infection is consistently associated with UNPC, we evaluated the diagnostic significance of EBV detection using a nonradioisotopic in situ hybridization assay. The data obtained by FNA from metastatic head and neck tumors was correlated with the histology of the corresponding surgical specimens. In a series of 25 FNA specimens of cervical lymph node metastases of tumors of unknown origin, EBV was found expressed in all seven metastases of UNPC but in none of 18 metastases of tumors of different types. Therefore, detection of EBV in cervical metastatic adenopathy may be successfully used to identify the presence of occult UNPC.
引用
收藏
页码:100 / 104
页数:5
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