A NEW MEMBER OF THE CYTOKINE RECEPTOR GENE FAMILY MAPS ON CHROMOSOME-21 AT LESS-THAN 35 KB FROM IFNAR

被引：76
作者：
LUTFALLA, G
GARDINER, K
UZE, G
机构：
[1] CNRS, IRSC, VIRAL ONCOL LAB, F-94801 VILLEJUIF, FRANCE
[2] ELEANOR ROOSEVELT INST CANC RES, DENVER, CO 80206 USA
来源：
GENOMICS | 1993年 / 16卷 / 02期
关键词：
D O I：
10.1006/geno.1993.1199
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
A full-length cDNA corresponding to a gene mapping to the D21S58 locus was cloned. The encoded protein, called CRF2-4, was shown to be a typical class II member of the cytokine receptor family. The gene encoding CRF2-4 spans more than 30 kb. Its intron/exon structure was determined and shown to be conserved with all other members of the cytokine receptor family. The physical distance between the CRF2-4 gene and its IFNAR neighbor has been narrowed to less than 35 kb. © 1993 Academic Press, Inc.
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页码：366 / 373
页数：8
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