ASSOCIATION ANALYSIS OF A POLYMORPHISM OF THE ANGIOTENSIN CONVERTING ENZYME GENE WITH ESSENTIAL-HYPERTENSION IN THE JAPANESE POPULATION

被引：138

作者：

HIGASHIMORI, K

ZHAO, Y

HIGAKI, J

KAMITANI, A

KATSUYA, T

NAKURA, J

MIKI, T

MIKAMI, H

OGIHARA, T

机构：

[1] Department of Geriatric Medicine, Osaka University Medical School, Osaka

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 191卷 / 02期

关键词：

D O I：

10.1006/bbrc.1993.1231

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An association study of the insertion/deletion (I/D) polymorphism located in intron 16 of the ACE gene with essential hypertension in the Japanese population was performed. The 287 bp I/D polymorphism was detected by polymerase chain reaction. Derived allele frequencies for insertion and deletion were not significantly different between 133 hypertensive and 104 normotensive subjects. A significant relationship between I/D polymorphism and plasma ACE activity was observed in the normotensive group, but not in hypertensives. These results suggest that I/D polymorphism of the gene is not implicated in Japanese hypertensive subjects, and that studies involving various ethnic groups are important. © 1993 Academic Press.

引用

收藏

页码：399 / 404

页数：6

相关论文

共 13 条

[1]

ERDOS EG, 1987, LAB INVEST, V56, P345

[2] CHROMOSOMAL MAPPING OF 2 GENETIC-LOCI ASSOCIATED WITH BLOOD-PRESSURE REGULATION IN HEREDITARY HYPERTENSIVE RATS [J].

HILBERT, P ;

LINDPAINTNER, K ;

BECKMANN, JS ;

SERIKAWA, T ;

SOUBRIER, F ;

DUBAY, C ;

CARTWRIGHT, P ;

DEGOUYON, B ;

JULIER, C ;

TAKAHASI, S ;

VINCENT, M ;

GANTEN, D ;

GEORGES, M ;

LATHROP, GM .

NATURE, 1991, 353 (6344) :521-529

[3] CLONING AND SEQUENCE-ANALYSIS OF CDNA FOR HUMAN RENIN PRECURSOR [J].

IMAI, T ;

MIYAZAKI, H ;

HIROSE, S ;

HORI, H ;

HAYASHI, T ;

KAGEYAMA, R ;

OHKUBO, H ;

NAKANISHI, S ;

MURAKAMI, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (24) :7405-7409

[4] GENETIC-MAPPING OF A GENE CAUSING HYPERTENSION IN THE STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RAT [J].

JACOB, HJ ;

LINDPAINTNER, K ;

LINCOLN, SE ;

KUSUMI, K ;

BUNKER, RK ;

MAO, YP ;

GANTEN, D ;

DZAU, VJ ;

LANDER, ES .

CELL, 1991, 67 (01) :213-224

[5] ABSENCE OF LINKAGE BETWEEN THE ANGIOTENSIN CONVERTING ENZYME LOCUS AND HUMAN ESSENTIAL-HYPERTENSION [J].

JEUNEMAITRE, X ;

LIFTON, RP ;

HUNT, SC ;

WILLIAMS, RR ;

LALOUEL, JM .

NATURE GENETICS, 1992, 1 (01) :72-75

[6]

KASAHARA Y, 1981, CLIN CHEM, V27, P1922

[7] A LACK OF GENETIC-LINKAGE OF RENIN GENE RESTRICTION FRAGMENT LENGTH POLYMORPHISMS WITH HUMAN HYPERTENSION [J].

NAFTILAN, AJ ;

WILLIAMS, R ;

BURT, D ;

PAUL, M ;

PRATT, RE ;

HOBART, P ;

CHIRGWIN, J ;

DZAU, VJ .

HYPERTENSION, 1989, 14 (06) :614-618

[8] AN INSERTION DELETION POLYMORPHISM IN THE ANGIOTENSIN I-CONVERTING ENZYME GENE ACCOUNTING FOR HALF THE VARIANCE OF SERUM ENZYME LEVELS [J].

RIGAT, B ;

HUBERT, C ;

ALHENCGELAS, F ;

CAMBIEN, F ;

CORVOL, P ;

SOUBRIER, F .

JOURNAL OF CLINICAL INVESTIGATION, 1990, 86 (04) :1343-1346

[9] SIMILAR FREQUENCIES OF RENIN GENE RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISMS IN HYPERTENSIVE AND NORMOTENSIVE SUBJECTS [J].

SOUBRIER, F ;

JEUNEMAITRE, X ;

RIGAT, B ;

HOUOT, AM ;

CAMBIEN, F ;

CORVOL, P .

HYPERTENSION, 1990, 16 (06) :712-717

[10]

TIRET L, 1992, AM J HUM GENET, V51, P197