ULTRASTRUCTURE OF THE JEJUNAL MUCOSA IN HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION

被引：23

作者：

MATHAN, MM

GRIFFIN, GE

MILLER, A

BATMAN, P

FORSTER, S

PINCHING, A

HARRIS, W

机构：

[1] ST GEORGE HOSP,SCH MED,DEPT COMMUNICABLE DIS,LONDON,ENGLAND

[2] ST GEORGE HOSP,SCH MED,DEPT HISTOPATHOL,LONDON,ENGLAND

[3] ST MARYS HOSP,SCH MED,DEPT MED,LONDON,ENGLAND

[4] ST MARYS HOSP,SCH MED,DEPT CLIN IMMUNOL,LONDON,ENGLAND

[5] ST MARYS HOSP,SCH MED,DEPT GENITOURINARY MED,LONDON,ENGLAND

来源：

JOURNAL OF PATHOLOGY | 1990年 / 161卷 / 02期

基金：

英国惠康基金;

关键词：

acquired immuno deficiency syndrome; HIV infection; jejunal biopsy; ultrastructure;

D O I：

10.1002/path.1711610206

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The ultrastructural changes in the jejunal muscosa of 11 male patients, three with clinical AIDS, five with AIDS related complex‐progressive generalized lymphadenopathy (ARC‐PGL), and three who were only HIV antibody positive, were studied. In the enterocytes, major abnormalities were proliferation of smooth endoplasmic reticulum mitochondrial changes, vacuolization of cells, and fat hold up. In the lamina propria, degeneration of enteric nerve axons and smooth muscle were seen. Microvasculature showed both endothelial cell degeneration and hyperplasia. The presence of tubuloreticular inclusions in endothelial cells paralleled the stage of the disease. Since none of the 11 patients had any opportunistic infection, these changes are likely to be the effect of HIV infection. Copyright © 1990 John Wiley & Sons, Ltd.

引用

页码：119 / 127

页数：9

共 34 条

[1] PRODUCTIVE, PERSISTENT INFECTION OF HUMAN COLORECTAL CELL-LINES WITH HUMAN-IMMUNODEFICIENCY-VIRUS [J].