ACTIVITY OF HUMAN VOLUNTEER SERA TO CANDIDATE PLASMODIUM-FALCIPARUM CIRCUMSPOROZOITE PROTEIN VACCINES IN THE INHIBITION OF SPOROZOITE INVASION ASSAY OF HUMAN HEPATOMA-CELLS AND HEPATOCYTES

被引：31
|
作者：
HOLLINGDALE, MR
APPIAH, A
LELAND, P
DOROSARIO, VE
MAZIER, D
PIED, S
HERRINGTON, DA
CHULAY, JD
BALLOU, WR
DERKS, T
YAP, SH
BEAUDOIN, RL
VERHAVE, JP
机构：
[1] UNIV MARYLAND,CTR VACCINE DEV,BALTIMORE,MD 21202
[2] GRP HOSP PITIE SALPETRIERE,F-75634 PARIS 13,FRANCE
[3] WALTER REED ARMY MED CTR,WASHINGTON,DC 20307
[4] CATHOLIC UNIV NIJMEGEN,NIJMEGEN,NETHERLANDS
[5] USN,MED RES INST,BETHESDA,MD 20814
来源：
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1990年 / 84卷 / 03期
关键词：
D O I：
10.1016/0035-9203(90)90303-V
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Sera from human volunteers immunized with either synthetic peptide (NANP)3-TT or recombinant protein R32tet32Plasmodium falciparum CS vaccines were tested in the inhibition of sporozoite invasion (ISI) assays using human hepatoma (HepG2-A16) cells or primary human hepatocytes. Sera or purified immunoglobulin (Ig) from volunteers who were completely protected against P. falciparum sporozoite challenge had higher ISI activity than sera from non-protected volunteers, or the highest titre endemic serum. However, Ig from protected and non-protected volunteers did not block sporozoite invasion of human hepatocytes, suggesting that P. falciparum sporozoites invade hepatocytes by mechanisms which differ from those concerned with invasion of HepG2-A16 cells. © 1990, Royal Society of Tropical Medicine and Hygiene. All rights reserved.
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收藏
页码：325 / 329
页数：5
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