CELLULAR-LOCALIZATION OF ATRIAL-NATRIURETIC-FACTOR IN THE HUMAN KIDNEY

被引:38
作者
FIGUEROA, CD
LEWIS, HM
MACIVER, AG
MACKENZIE, JC
BHOOLA, KD
机构
[1] UNIV BRISTOL, SCH MED, DEPT PHARMACOL, BRISTOL BS8 1TD, AVON, ENGLAND
[2] UNIV BRISTOL, SCH MED, DEPT NEPHROL, BRISTOL BS8 1TD, AVON, ENGLAND
[3] UNIV BIRMINGHAM, SCH MED, DEPT PHARMACOL, BIRMINGHAM B15 2TT, W MIDLANDS, ENGLAND
[4] UNIV BRISTOL, SCH MED, DEPT PATHOL, BRISTOL BS8 1TD, AVON, ENGLAND
关键词
Atrial natriuretic factor; Collecting ducts Tissue kallikrein; Connecting tubules; Distal tubule cells; Intercalated cells;
D O I
10.1093/ndt/5.1.25
中图分类号
R3 [基础医学]; R4 [临床医学];
学科分类号
1001 ; 1002 ; 100602 ;
摘要
We have localised atrial natriuretic factor (ANF) in the human kidney by immunocytochemistry and radioimmunoassay.ANF is specifically visualised in the distal convoluted tubule cells and the intercalated cells of the connecting tubules and collecting ducts of the human nephron. The number of immunoreactive cells and tissue values for the peptide were compared between samples from normal kidneys and biopsies obtained from hypertensive patients, in whom the tissue ANF immunoreactivity was found to be reduced.Specific experiments are necessary to establish whether renal ANF is synthesised de novo or captured through endocytosis by the renal tubular cells.The possible functional roles of renal ANF are discussed. © 1990 European Dialysis and Transplant Association-European Renal Association.
引用
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页码:25 / 31
页数:7
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