Metabolic profiling of plasma from cardiac surgical patients concurrently administered with tranexamic acid: DI-SPME-LC-MS analysis

被引：14

作者：

Bojko, Barbara ^{[1
]}

Wasowicz, Marcin ^{[2
]}

Pawliszyn, Janusz ^{[1
]}

机构：

[1] Univ Waterloo, Dept Chem, 200 Univ Ave West, Waterloo, ON N2L 3G1, Canada

[2] Toronto Gen Hosp, Dept Anesthesia, Toronto, ON M5G 2C4, Canada

来源：

JOURNAL OF PHARMACEUTICAL ANALYSIS | 2014年 / 4卷 / 01期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Metabolomics; Heart surgery; Cardiopulmonary bypass; Tranexamic acid; Direct immersion solid phase microextraction; LC/MS;

D O I：

10.1016/j.jpha.2013.03.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A metabolic profile of plasma samples from patients undergoing heart surgery with the use of cardiopulmonary bypass (CPB) and concurrent administration of tranexamic acid was determined. Direct immersion solid phase microextraction (DI-SPME), a new sampling and sample preparation tool for metabolomics, was used in this study for the first time to investigate clinical samples. The results showed alteration of diverse compounds involved in different biochemical pathways. The most significant contribution in changes induced by swgery and applied pharmacotherapy was noticed in metabolic profile of lysophospholipids, triacylglycerols, mediators of platelet aggregation, and linoleic acid metabolites. Two cases of individual response to treatment were also reported. (C) 2013 Xi'an Jiaotong University. Production and hosting by Elsevier B.V. All rights reserved.

引用

页码：6 / 13

页数：8

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