Molecular and biochemical pharmacology of the histamine H4 receptor

被引：113
作者：
Leurs, Rob [1 ]
Chazot, Paul L. [2 ]
Shenton, Fiona C. [2 ]
Lim, Herman D. [1 ]
de Esch, Iwan J. P. [1 ]
机构：
[1] Vrije Univ Amsterdam, Dept Med Chem, Leiden Amsterdam Ctr Drug Res, NL-1081 HV Amsterdam, Netherlands
[2] Univ Durham, Sch Biol & Biomed Sci, Durham, England
来源：
BRITISH JOURNAL OF PHARMACOLOGY | 2009年 / 157卷 / 01期
关键词：
histamine H-4 receptor; molecular pharmacology; biochemistry; signal transduction; species difference; isoforms; heterogeneity; selective agonists and antagonists; AGONIST BINDING; SPLICE VARIANTS; H4; RECEPTOR; FUNCTIONAL EXPRESSION; MEDIATES CHEMOTAXIS; HUMAN EOSINOPHILS; CRYSTAL-STRUCTURE; N-GLYCOSYLATION; 1ST POTENT; CLONING;
D O I：
10.1111/j.1476-5381.2009.00250.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The elucidation of the human genome has had a major impact on histamine receptor research. The identification of the human H-4 receptor by several groups has been instrumental for a new appreciation of the role of histamine in the modulation of immune function. In this review, we summarize the historical developments and the molecular and biochemical pharmacology of the H-4 receptor.
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收藏
页码：14 / 23
页数：10
相关论文
共 80 条
[1]  
[Anonymous], [No title captured], Patent No. [US 20050070527A1, 20050070527]
[2]   AUTO-INHIBITION OF BRAIN HISTAMINE-RELEASE MEDIATED BY A NOVEL CLASS (H-3) OF HISTAMINE-RECEPTOR [J].
ARRANG, JM ;
GARBARG, M ;
SCHWARTZ, JC .
NATURE, 1983, 302 (5911) :832-837
[3]   RECEPTORS MEDIATING SOME ACTIONS OF HISTAMINE [J].
ASH, ASF ;
SCHILD, HO .
BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, 1966, 27 (02) :427-&
[4]   Histamine H4 receptors modulate dendritic cell migration through skin -: immunomodulatory role of histamine [J].
Baeumer, W. ;
Wendorff, S. ;
Gutzmer, R. ;
Werfel, T. ;
Dijkstra, D. ;
Chazot, P. ;
Stark, H. ;
Kietzmann, M. .
ALLERGY, 2008, 63 (10) :1387-1394
[5]   Discovery of naturally occurring splice variants of the rat histamine H3 receptor that act as dominant-negative isoforms [J].
Bakker, RA ;
Lozada, AF ;
van Marle, A ;
Shenton, FC ;
Drutel, G ;
Karlstedt, K ;
Hoffmann, M ;
Lintunen, M ;
Yamamoto, Y ;
van Rijn, RM ;
Chazot, PL ;
Panula, P ;
Leurs, R .
MOLECULAR PHARMACOLOGY, 2006, 69 (04) :1194-1206
[6]  
Ballesteros J. A., 1995, METH NEUROSCI, P366, DOI [DOI 10.1016/S1043-9471(05)80049-7, DOI 10.1016/S1043-9471]
[7]   Histamine-induced actin polymerization in human eosinophils:: An imaging approach for histamine H4 receptor [J].
Barnard, Ruth ;
Barnard, Adrian ;
Salmon, Gary ;
Liu, Wai ;
Sreckovic, Sasha .
CYTOMETRY PART A, 2008, 73A (04) :299-304
[8]   Involvement of histamine H4 and H1 receptors in scratching induced by histamine receptor agonists in BalbC mice [J].
Bell, JK ;
McQueen, DS ;
Rees, JL .
BRITISH JOURNAL OF PHARMACOLOGY, 2004, 142 (02) :374-380
[9]   DEFINITION AND ANTAGONISM OF HISTAMINE H2-RECEPTORS [J].
BLACK, JW ;
PARSONS, EM ;
DURANT, CJ ;
DUNCAN, WAM ;
GANELLIN, CR .
NATURE, 1972, 236 (5347) :385-&
[10]   Molecular aspects of the histamine H3 receptor [J].
Bongers, Gerold ;
Bakker, Remko A. ;
Leurs, Rob .
BIOCHEMICAL PHARMACOLOGY, 2007, 73 (08) :1195-1204
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