GLUCOCORTICOID-INDUCED DOWN-REGULATION OF TRANSFORMING GROWTH-FACTOR-BETA-1 IN ADULT-RAT LUNG FIBROBLASTS

被引：25
|
作者：
SHULL, S
MEISLER, N
ABSHER, M
PHAN, S
CUTRONEO, K
机构：
[1] UNIV VERMONT, COLL MED, DEPT BIOCHEM, BURLINGTON, VT 05405 USA
[2] UNIV VERMONT, COLL MED, DEPT MED, BURLINGTON, VT 05405 USA
[3] UNIV MICHIGAN, SCH MED, DEPT PATHOL, ANN ARBOR, MI 48109 USA
来源：
LUNG | 1995年 / 173卷 / 02期
关键词：
GLUCOCORTICOIDS; DEXAMETHASONE; TRANSFORMING GROWTH FACTOR-BETA-1; RAT LUNG FIBROBLASTS;
D O I：
10.1007/BF02981467
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Transforming growth factor-beta 1 mRNA and transforming growth factor beta activity are decreased with exposure of normal adult rat lung fibroblasts to dexamethasone. Dexamethasone caused a decrease in transforming growth factor-beta 1 mRNA within 2 hours, which was sustained at least over a 24-hour period. The decrease in transforming growth factor-beta 1 mRNA was dose related. Dexamethasone treatment of rat lung fibroblasts also resulted in a decrease of transforming growth factor beta activity as determined by the mink lung cell growth inhibition assay. These data indicate that glucocorticoids may regulate collagen synthesis at least in part through the mediation of transforming growth factor-beta 1 rat lung fibroblasts.
引用
收藏
页码：71 / 78
页数：8
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