THE CONJUGATION OF PROTEINS WITH POLYETHYLENE-GLYCOL AND OTHER POLYMERS - ALTERING PROPERTIES OF PROTEINS TO ENHANCE THEIR THERAPEUTIC POTENTIAL

被引：213
作者：
KATRE, NV
机构：
来源：
ADVANCED DRUG DELIVERY REVIEWS | 1993年 / 10卷 / 01期
关键词：
PROTEIN MODIFICATION; PHARMACOKINETICS; POLYETHYLENE GLYCOL; DRUG-DELIVERY; PROTEIN-POLYMER ADDUCTS; PHARMACEUTICAL APPLICATIONS;
D O I：
10.1016/0169-409X(93)90005-O
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The development of protein drugs for therapeutic purposes using recombinant DNA technology has generated a great deal of interest in methods of enhancing their delivery. One method of improving the delivery of proteins, and thereby increasing their therapeutic index, is covalent conjugation to polymers. This paper discusses polymers which are suitable for conjugation, methods of conjugation, the properties of polymer-protein conjugates and possibilities for designing drug delivery systems using these conjugates. The properties of protein-polymer conjugates include a dramatic increase in bioavailability, decreased immunogenicity, and enhanced solubility and stability. These altered properties improve the delivery and efficacy of proteins and impart a flexibility to their clinical usage.
引用
收藏
页码：91 / 114
页数：24
相关论文
共 125 条
[21]   INSTABILITY OF SUCCINYL ESTER LINKAGES IN O2'-MONOSUCCINYL CYCLIC AMP-PROTEIN CONJUGATES AT NEUTRAL PH [J].
CARTER, MC ;
MEYERHOFF, ME .
JOURNAL OF IMMUNOLOGICAL METHODS, 1985, 81 (02) :245-257
[22]   IGG ANTIBODY-RESPONSE TO POLYETHYLENE GLYCOL-MODIFIED ADENOSINE-DEAMINASE IN PATIENTS WITH ADENOSINE-DEAMINASE DEFICIENCY [J].
CHAFFEE, S ;
MARY, A ;
STIEHM, ER ;
GIRAULT, D ;
FISCHER, A ;
HERSHFIELD, MS .
JOURNAL OF CLINICAL INVESTIGATION, 1992, 89 (05) :1643-1651
[23]   PROPERTIES OF 2 URATE OXIDASES MODIFIED BY THE COVALENT ATTACHMENT OF POLY(ETHYLENE GLYCOL) [J].
CHEN, RHL ;
ABUCHOWSKI, A ;
VANES, T ;
PALCZUK, NC ;
DAVIS, FF .
BIOCHIMICA ET BIOPHYSICA ACTA, 1981, 660 (02) :293-298
[24]  
DAVIS FF, 1980, SOLUBLE NONANTIGENIC, P441
[25]  
DREBORG S, 1990, CRIT REV THER DRUG, V6, P315
[26]   IMMEDIATE AND DELAYED ALLERGIC CONTACT REACTIONS TO POLYETHYLENE-GLYCOL [J].
FISHER, AA .
CONTACT DERMATITIS, 1978, 4 (03) :135-138
[27]   PREPARATION OF POLYETHYLENE GLYCOL-BOUND NAD AND ITS APPLICATION IN A MODEL ENZYME REACTOR [J].
FURUKAWA, S ;
KATAYAMA, N ;
IIZUKA, T ;
URABE, I ;
OKADA, H .
FEBS LETTERS, 1980, 121 (02) :239-242
[28]   THE PREPARATION AND PROPERTIES OF NOVEL REVERSIBLE POLYMER-PROTEIN CONJUGATES - 2-OMEGA-METHOXYPOLYETHYLENE (5000) GLYCOXYMETHYLENE-3-METHYLMALEYL CONJUGATES OF PLASMINOGEN ACTIVATORS [J].
GARMAN, AJ ;
KALINDJIAN, SB .
FEBS LETTERS, 1987, 223 (02) :361-365
[29]  
Gebelein CG., 1985, BIOACTIVE POLYM SYST, P1, DOI [10.1007/978-1-4757-0405-1, DOI 10.1007/978-1-4757-0405-1]
[30]   4-PHENOXY-3,5-DINITROBENZOYLPOLYETHYLENEGLYCOL - REVERSIBLE ATTACHMENT OF CYSTEINE-CONTAINING POLYPEPTIDES TO POLYMERS IN AQUEOUS-SOLUTIONS [J].
GLASS, JD ;
SILVER, L ;
SONDHEIMER, J ;
PANDE, CS ;
CODERRE, J .
BIOPOLYMERS, 1979, 18 (02) :383-392
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