THE ANTIHYPERTENSIVE AND POSITIVE INOTROPIC DITERPENE FORSKOLIN - EFFECTS OF STRUCTURAL MODIFICATIONS ON ITS ACTIVITY

被引：105

作者：

BHAT, SV ^{[1
]}

DOHADWALLA, AN ^{[1
]}

BAJWA, BS ^{[1
]}

DADKAR, NK ^{[1
]}

DORNAUER, H ^{[1
]}

DESOUZA, NJ ^{[1
]}

机构：

[1] HOECHST PHARMACEUT LTD,RES CTR,BOMBAY 400080,INDIA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1983年 / 26卷 / 04期

关键词：

D O I：

10.1021/jm00358a006

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：486 / 492

页数：7

共 16 条

[1]

ARIENS EJ, 1971, DRUG DESIGN, V2, pCH1

[2]

BHAT S V, 1977, Tetrahedron Letters, V19, P1669

[3] REACTIONS OF FORSKOLIN, A BIOLOGICALLY-ACTIVE DITERPENOID FROM COLEUS-FORSKOHLII [J].

BHAT, SV ;

BAJWA, BS ;

DORNAUER, H ;

DESOUZA, NJ .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1982, (03) :767-771

[4] ROLE OF PERIPHERAL VASCULAR-RESISTANCE AND REACTIVITY IN INTERACTION BETWEEN CLONIDINE AND IMIPRAMINE IN SPONTANEOUSLY HYPERTENSIVE RATS [J].

DADKAR, NK ;

DOHADWALLA, AN ;

BHATTACHARYA, BK .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1978, 30 (01) :58-60

[5] ACTIVATION OF CYCLIC AMP-GENERATING SYSTEMS IN BRAIN MEMBRANES AND SLICES BY THE DITERPENE FORSKOLIN - AUGMENTATION OF RECEPTOR-MEDIATED RESPONSES [J].

DALY, JW ;

PADGETT, W ;

SEAMON, KB .

JOURNAL OF NEUROCHEMISTRY, 1982, 38 (02) :532-544

[6] FORSKOLIN - A LABDANE DITERPENOID WITH ANTIHYPERTENSIVE, POSITIVE INOTROPIC, PLATELET-AGGREGATION INHIBITORY, AND ADENYLATE-CYCLASE ACTIVATING PROPERTIES [J].

DESOUZA, NJ ;

DOHADWALLA, AN ;

REDEN, J .

MEDICINAL RESEARCH REVIEWS, 1983, 3 (02) :201-219

[7]

LINDNER E, 1978, ARZNEIMITTEL-FORSCH, V28-1, P284

[8]

LITCHFIELD JT, 1949, J PHARMACOL EXP THER, V96, P99

[9]

LIVINGSTONE E, 1970, PHARM EXPT ISOLATED, P112

[10]

METZGER H, 1981, IRCS MED SCI-BIOCHEM, V9, P99

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