THROMBOSPONDIN IS PRESENT IN ARTICULAR-CARTILAGE AND IS SYNTHESIZED BY ARTICULAR CHONDROCYTES

被引：42

作者：

MILLER, RR

MCDEVITT, CA

机构：

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1988年 / 153卷 / 02期

关键词：

D O I：

10.1016/S0006-291X(88)81152-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Thrombospondin, a multifunctional adhesive glycoprotein originally identified in platelets, was isolated and identified from an extract of ovine articular cartilage. Immunoreactive material from a cartilage extract comigrated on gel electrophoresis with purified human platelet thrombospondin. When articular chondrocytes were cultured in the presence of 35S-methionine, metabolically labeled thrombospondin was immunoprecipitated from the culture medium and cell layer extract. These results demonstrate that thrombospondin is present in articular cartilage and is synthesized by articular chondrocytes.

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页码：708 / 714

页数：7

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