CHARACTERIZATION OF A PLASMODIUM-FALCIPARUM MEROZOITE SURFACE-ANTIGEN TARGETED BY DEFENSE-MECHANISMS DEVELOPED IN IMMUNE INDIVIDUALS

被引：0
作者：
OEUVRAY, C
BOUHAROUNTAYOUN, H
FILGUEIRA, MC
GRASMASSE, H
TARTAR, A
DRUILHE, P
机构：
[1] INST PASTEUR,PARASITOL MED LAB,28 RUE DU DOCTEUR ROUX,F-75724 PARIS 15,FRANCE
[2] INST PASTEUR,CHIM BIOMOLEC LAB,CNRS,IRA 1309,F-59019 LILLE,FRANCE
来源：
COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE III-SCIENCES DE LA VIE-LIFE SCIENCES | 1993年 / 316卷 / 04期
关键词：
MALARIA; PROTECTION; ANTIBODIES; MEROZOITE;
D O I：
暂无
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We report the identification of a 48 kDa antigen targetted by antibodies which inhibit P. falciparum in vitro growth by cooperation with blood monocytes in an ADCl assay correlated to the naturally acquired protection. This protein is located on the surface of the merozoite stage, and is detectable in all isolates tested.
引用
收藏
页码：395 / 399
页数：5
相关论文
共 14 条
  • [1] PLASMODIUM-FALCIPARUM - CHARACTERIZATION OF GENE R45 ENCODING A TROPHOZOITE ANTIGEN CONTAINING A CENTRAL BLOCK OF 6 AMINO-ACID REPEATS
    BONNEFOY, S
    GUILLOTTE, M
    LANGSLEY, G
    MERCEREAUPUIJALON, O
    [J]. EXPERIMENTAL PARASITOLOGY, 1992, 74 (04) : 441 - 451
  • [2] BORDIER C, 1981, J BIOL CHEM, V256, P1604
  • [3] ANTIBODIES THAT PROTECT HUMANS AGAINST PLASMODIUM-FALCIPARUM BLOOD STAGES DO NOT ON THEIR OWN INHIBIT PARASITE GROWTH AND INVASION INVITRO, BUT ACT IN COOPERATION WITH MONOCYTES
    BOUHAROUNTAYOUN, H
    ATTANATH, P
    SABCHAREON, A
    CHONGSUPHAJAISIDDHI, T
    DRUILHE, P
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 172 (06) : 1633 - 1641
  • [4] PLASMODIUM-FALCIPARUM MALARIA - EVIDENCE FOR AN ISOTYPE IMBALANCE WHICH MAY BE RESPONSIBLE FOR DELAYED ACQUISITION OF PROTECTIVE IMMUNITY
    BOUHAROUNTAYOUN, H
    DRUILHE, P
    [J]. INFECTION AND IMMUNITY, 1992, 60 (04) : 1473 - 1481
  • [5] GLYCOLIPID ANCHORAGE OF PLASMODIUM-FALCIPARUM SURFACE-ANTIGENS
    BRETON, CB
    ROSENBERRY, TL
    DASILVA, LHP
    [J]. RESEARCH IN IMMUNOLOGY, 1990, 141 (08): : 743 - 755
  • [6] DRUILHE P, 1992, RES IMMUNOL, V142, P637
  • [7] GUERINMARCHAND C, 1987, NATURE, V329, P1164
  • [8] MUNG BEAN NUCLEASE CLEAVES PLASMODIUM GENOMIC DNA AT SITES BEFORE AND AFTER GENES
    MCCUTCHAN, TF
    HANSEN, JL
    DAME, JB
    MULLINS, JA
    [J]. SCIENCE, 1984, 225 (4662) : 625 - 628
  • [9] PLASMODIUM-FALCIPARUM - ISOLATION AND PURIFICATION OF SPONTANEOUSLY RELEASED MEROZOITES BY NYLON MEMBRANE SIEVES
    MREMA, JEK
    LANGRETH, SG
    JOST, RC
    RIECKMANN, KH
    HEIDRICH, HG
    [J]. EXPERIMENTAL PARASITOLOGY, 1982, 54 (03) : 285 - 295
  • [10] PARASITOLOGICAL AND CLINICAL HUMAN RESPONSE TO IMMUNOGLOBULIN ADMINISTRATION IN FALCIPARUM-MALARIA
    SABCHAREON, A
    BURNOUF, T
    OUATTARA, D
    ATTANATH, P
    BOUHAROUNTAYOUN, H
    CHANTAVANICH, P
    FOUCAULT, C
    CHONGSUPHAJAISIDDHI, T
    DRUILHE, P
    [J]. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1991, 45 (03) : 297 - 308
12