CHEMISTRY OF O,N-HETEROCYCLES AND S,N-HETEROCYCLES .10. SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 2-SUBSTITUTED 2-ETHYLBENZOXAZOLES

被引：5

作者：

BARTSCH, H

ERKER, T

机构：

[1] Institut für Pharmazeutische Chemie, Universität Wien, Wien, A-1090

来源：

ARCHIV DER PHARMAZIE | 1991年 / 324卷 / 02期

关键词：

D O I：

10.1002/ardp.19913240204

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

2-Vinylbenzoxazole (3) is obtained by condensation of acrylic acid with 2-aminophenol in a mixture of phosphorus pentoxide/methansulfonic acid. Interaction of 3 with N-, O-, and C-nucleophiles yields 2-substituted 2-ethyl-benzoxazoles. Compounds 8a, 8b and 8e show analgetic activity in mice. Moreover, fungicide, insecticide and nematocide activity of some compounds is found.

引用

页码：79 / 82

页数：4

共 8 条

[1]

BARTSCH H, 1988, LIEBIGS ANN CHEM, P795

[2]

DOMINO EF, 1952, J PHARMACOL EXP THER, V105, P486

[3] PHOSPHORUS PENTOXIDE-METHANESULFONIC ACID - CONVENIENT ALTERNATIVE TO POLYPHOSPHORIC ACID [J].