THE NOVEL INOSITOL LIPID PHOSPHATIDYLINOSITOL 3,4-BISPHOSPHATE IS PRODUCED BY HUMAN BLOOD-PLATELETS UPON THROMBIN STIMULATION

被引：61

作者：

SULTAN, C ^{[1
]}

BRETON, M ^{[1
]}

MAUCO, G ^{[1
]}

GRONDIN, P ^{[1
]}

PLANTAVID, M ^{[1
]}

CHAP, H ^{[1
]}

机构：

[1] HOP PURPAN,INSERM,U326,F-31059 TOULOUSE,FRANCE

来源：

BIOCHEMICAL JOURNAL | 1990年 / 269卷 / 03期

关键词：

D O I：

10.1042/bj2690831

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Radioactive PtdIns(3)P was detected in human platelets incubated with [32P]P(i), but remained unaffected by thrombin treatment. In contrast, [32P]PtdIns(3,4)P2 was absent from resting platelets, but was produced by thrombin-activated platelets in a dose- and time-dependent manner. [32P]PtdInsP3 was never found under these conditions. These changes are similar to those elicited in other cells by platelet-derived growth factor or the oncogene product pp60(c-src).

引用

页码：831 / 834

页数：4

共 25 条

[11] EFFECTS OF ACETYLCHOLINE ON THE TURNOVER OF PHOSPHORYL UNITS IN INDIVIDUAL PHOSPHOLIPIDS OF PANCREAS SLICES AND BRAIN CORTEX SLICES [J].