SYNTHESIS OF 6-C-SUBSTITUTED PURINE NUCLEOSIDES - ALPHA-(AMINOMETHYLENE)-9-BETA-D-RIBOFURANOSYLPURINE-6-ACETIC ACID-DERIVATIVES

被引：0

作者：

HAMAMICHI, N ^{[1
]}

MIYASAKA, T ^{[1
]}

机构：

[1] SHOWA UNIV, SCH PHARMACEUT SCI, SHINAGAWA KU, TOKYO 142, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1992年 / 40卷 / 04期

关键词：

PURINE; ENAMINO-AMIDE; ENAMINO-ETHYL ESTER; CATALYTIC HYDROGENATION; RIBOFURANOSE;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Alpha-(aminomethylene)-beta-D-ribofuranosylpurine-6-acetamide (4) and the ethyl acetate (9) have been synthesized by catalytic hydrogenation of 6-cyanomethylenepurine derivatives (3 and 7). 6-Cyanomethylenepurines were obtained by substitution of 6-chloro-9-(2,3-O-isopropylidene-beta-D-ribofuranosyl)purine (1) with alpha-cyanoacetamide and ethyl cyanoacetate, followed by deprotection of the isopropylidene group. Substitution of 4 and 9 with benzylamine and aniline gave the corresponding N-benzyl- and N-phenyl-substituted alpha-(aminomethylene)-beta-D-ribofuranosylpurine-6-acetamides (5) and the ethyl acetate (10), respectively.

引用

页码：843 / 845

页数：3

共 15 条

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