MELATONIN POTENTIATES CYCLIC-AMP PRODUCTION STIMULATED BY VASOACTIVE-INTESTINAL-PEPTIDE IN HUMAN-LYMPHOCYTES

被引：23

作者：

LOPEZGONZALEZ, MA ^{[1
]}

CALVO, JR ^{[1
]}

OSUNA, C ^{[1
]}

RUBIO, A ^{[1
]}

GUERRERO, JM ^{[1
]}

机构：

[1] UNIV SEVILLE,SCH MED,DEPT MED BIOCHEM & MOLEC BIOL,AVDA SANCHEZ PIZJUAN 4,E-41009 SEVILLE,SPAIN

来源：

NEUROSCIENCE LETTERS | 1992年 / 136卷 / 02期

关键词：

MELATONIN; LYMPHOCYTE; VASOACTIVE INTESTINAL PEPTIDE; CYCLIC AMP;

D O I：

10.1016/0304-3940(92)90036-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present paper demonstrates the effect of melatonin on cyclic AMP production in human lymphocytes from peripheral blood. Melatonin by itself did not influence cyclic AMP accumulation in these cells at any dose studied; however, the drug potentiated the effect of vasoactive intestinal peptide (VIP) on the cyclic nucleotide production. In the presence of physiological concentrations of VIP (either 1, 10 or 100 pM), melatonin potentiated cyclic AMP production. However, at high doses of VIP (either 1, 10 or 100 nM), melatonin exhibited no such effect. The results suggest that human lymphocytes are a target for melatonin and that it may participate, jointly with VIP, in the regulation of immune function.

引用

页码：150 / 152

页数：3

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