EFFECT OF THIAMIN DEFICIENCY ON ENERGY METABOLITES IN THE TURKEY

The effects of thiamin deficiency on selected energy-related metabolites was investigated. A basal diet (B) was formulated to be 11% of NRC recommended level of 2 mg/kg of thiamin. Thiamin was added to this basal diet to generate the control diet (C). Twenty one-week-old female turkeys were fed either the B or C diet. On days four and five of the experiment, food intake was decreased significantly in B fed turkeys (P < 0.05). Plasma and brain samples were collected at this time. Brains were dissected and analyzed for ATP, ADP, uric acid, free fatty acids, glucose, and GABA. Adenosine triphosphate and the ATP/ADP ratio were decreased in the hindbrain (medulla-pons area) of thiamin deficient birds (P < 0.01). Uric acid was increased (P < 0.001) and free fatty acids were decreased (P < 0.0005) in the plasma of thiamin deficient birds. Based on the data, changes in ATP and ATP/ADP levels may be related to the anorectic behavior exhibited by the thiamin deficient bird. © 1990.