ANTIFUNGAL ACTIVITY OF FUMARIC-ACID IN MICE INFECTED WITH CANDIDA-ALBICANS

被引：0
|
作者：
AKAO, M
KURODA, K
机构：
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1991年 / 39卷 / 11期
关键词：
FUMARIC ACID; CANDIDA-ALBICANS; SYSTEMIC MYCOSIS; ANTIFUNGAL ACTIVITY;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
An examination was made on the effect of fumaric acid on an experimental systemic candidiasis. Male ICR mice were innoculated into the tail veins with 10(6) yeast cells of Candida albicans and treated with daily intraperitoneal injections of fumaric acid at the dose of 40 mg/kg/d. The results indicated that the administration of fumaric acid was effective in prolonging the survival of animals after the fungal challenge and prevented one-fifth of the treated animals from dying of candidiasis.
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页码：3077 / 3078
页数：2
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