Non-invasive assessment of barrier integrity and function of the human gut

被引：165
作者：
Grootjans, Joep [1 ,2 ]
Thuijls, Geertje [1 ,2 ]
Verdam, Froukje [1 ,2 ]
Derikx, Joep P. M. [1 ,2 ]
Lenaerts, Kaatje [1 ,2 ]
Buurman, Wim A. [1 ,2 ]
机构：
[1] Maastricht Univ, Med Ctr, Dept Surg, Univ Singel 50, NL-6229 ER Maastricht, Netherlands
[2] NUTRIM Sch Nutr Toxicol & Metab, NL-6229 ER Maastricht, Netherlands
来源：
WORLD JOURNAL OF GASTROINTESTINAL SURGERY | 2010年 / 2卷 / 03期
关键词：
Intestinal integrity; Intestinal barrier function; Intestinal permeability; Markers;
D O I：
10.4240/wjgs.v2.i3.61
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Over the past decades evidence has been accumulating that intestinal barrier integrity loss plays a key role in the development and perpetuation of a variety of disease states including inflammatory bowel disease and celiac disease, and is a key player in the onset of sepsis and multiple organ failure in situations of intestinal hypoperfusion, including trauma and major surgery. Insight into gut barrier integrity and function loss is important to improve our knowledge on disease etiology and pathophysiology and contributes to early detection and/or secondary prevention of disease. A variety of tests have been developed to assess intestinal epithelial cell damage, intestinal tight junction status and consequences of intestinal barrier integrity loss, i.e. increased intestinal permeability. This review discusses currently available methods for evaluating loss of human intestinal barrier integrity and function. (C) 2010 Baishideng. All rights reserved.
引用
收藏
页码：61 / 69
页数：9
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