PHYSICOCHEMICAL PROPERTIES AND BIOLOGICAL-ACTIVITIES OF ERYTHROMYCIN NALIDIXATE

被引：0

作者：

GOSWAMI, BB

MANNA, PK

BASU, SK

机构：

来源：

ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH | 1995年 / 45卷 / 07期

关键词：

ANTIMICROBIAL AGENTS; ERYTHROMYCIN NALIDIXATE; IN VITRO STUDIES; PHYSICOCHEMICAL PROPERTIES;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Erythromycin nalidixate was prepared by combining nalidixic acid with erythromycin base. Thin-layer chromatographic studies and infrared absorption spectrum confirmed homogeneity of the new salt. The salt is very soluble in nonpolar solvent and freely soluble in polar solvent. The salt is quite stable at room temperature (30 +/- 1 degrees C). The antimicrobially active dose of the salt was found to be 820 mu g/mg. Serum protein binding amounted to 85% and was reversible LD(50) in mice was found to be 371.5 mg/kg when the intraperitoneal route was used.

引用

页码：813 / 814

页数：2