IMMUNOLOCALIZATION OF EXTRACELLULAR-MATRIX MACROMOLECULES IN THE RAT SPINAL-CORD

被引：17

作者：

AZZI, G ^{[1
]}

JOUIS, V ^{[1
]}

GODEAU, G ^{[1
]}

GROULT, N ^{[1
]}

ROBERT, AM ^{[1
]}

机构：

[1] UNIV PARIS 12,FAC MED,CNRS,UA 1174,BIOCHIM TISSU CONJONCT LAB,8 RUE GEN SARRAIL,F-94010 CRETEIL,FRANCE

来源：

MATRIX | 1990年 / 9卷 / 06期

关键词：

extracellular matrix; immunohistochemistry; rat; spinal cord;

D O I：

10.1016/S0934-8832(11)80017-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Extracellular matrix macromolecules are involved in many aspects of cell biology. The knowledge concerning the presence, the distribution and the role of these macromolecules in the central nervous system has not yet received sufficient attention. In the present work we studied by indirect immunohistochemical methods the localisation of five extracellular matrix macromolecules in the spinal cord of rats: three collagens: type I, type III, and type IV, and two structural glycoproteins: laminin and fibronectin. We found that all five macromolecules are present in the spinal cord of normal animals. They are localised exclusively in the connective type tissues: the meningeal sheets and the vascular walls. Only type I and type III collagens and fibronectin could be demonstrated around the epithelial cells of the ependyma. © 1989, Gustav Fischer Verlag · Stuttgart · New York. All rights reserved.

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页码：479 / 485

页数：7

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