THE POLAROGRAPHIC-DETERMINATION OF FLUVOXAMINE MALEATE

In this study, the polarographic behaviour and the optimum polarographic conditions for the determination of fluvoxamine using DC, DP and SIAP techniques are described based on the reduction on the DME. The experiments were conducted in the aqueous supporting electrolyte containing 0.2 M KCI, 20 % ethanol (v/v) and 0.2 M buffer solution. Single waves were obtained at various pH values. The limiting currents were decreased and E(1/2) values were linearly shifted to more negative potentials with an increase of pH. The system was irreversible at both the acidic and the basic medium and was controlled by adsorption at pH 4.2 and by diffusion at pH 8.03. The variation of the limiting current against temperature was found to be 1.1 mu A/degrees C. Good calibration relations were obtained for DC (direct current), DP (differential pulse) and SIAP (superimposed increasing amplitude pulse) techniques. The determination of fluvoxamine in a pharmaceutical preparation, Faverin(R) Tablets containing 50 mg of fluvoxamine, were tested. The results were compared to those of UV-spectrophotometric method. In the analysis of a single 50 mp tablet, the relative standard deviation (S-rel) are found to be between +/-0.5 and +/-1.0 for the techniques employed for filtered and unfiltered solutions. The polarographic techniques used for the determination of fluvoxamine seem to be accurate, rapid and practical. Therefore, the suggested method may be promising in the routine analysis.