FC-GAMMA RECEPTOR-II STIMULATED FORMATION OF INOSITOL PHOSPHATES IN HUMAN PLATELETS IS BLOCKED BY TYROSINE KINASE INHIBITORS AND ASSOCIATED WITH TYROSINE PHOSPHORYLATION OF THE RECEPTOR

被引:28
作者
BLAKE, RA
ASSELIN, J
WALKER, T
WATSON, SP
机构
[1] Department of Pharmacology, Oxford, OX1 3QT, Mansfield Road
关键词
FC-GAMMA RECEPTOR; PHOSPHOLIPASE C; TYROSINE PHOSPHORYLATION; HUMAN PLATELET; IMMUNE COMPLEX; TYROSINE KINASE INHIBITOR;
D O I
10.1016/0014-5793(94)80575-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We report that activation of phospholipase C (PLC) by cross-linking of the platelet low-affinity Fc gamma receptor II (Fc gamma RII) is inhibited by two structurally distinct tyrosine kinase inhibitors, staurosporine and ST271. This contrasts with PLC activation induced by thrombin and U46619, a thromboxane mimetic, whose receptors have seven transmembrane domains characteristic of G-protein coupled receptors. Several proteins undergo phosphorylation on tyrosine on Fc gamma RII cross-linking upstream of protein kinase C (PKC), Ca2+ and aggregation, including the Fc gamma RII itself. The role of Fc gamma RII phosphorylation in the regulation of PLC is discussed.
引用
收藏
页码:15 / 18
页数:4
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