NORMAL MITOCHONDRIAL GENOME IN BRAIN FROM PATIENTS WITH PARKINSONS-DISEASE AND COMPLEX-I DEFECT

被引：138

作者：

LESTIENNE, P

NELSON, J

RIEDERER, P

JELLINGER, K

REICHMANN, H

机构：

[1] UNIV WURZBURG,DEPT NEUROL,JOSEF SCHNEIDER STR 11,W-8700 WURZBURG,GERMANY

[2] LAINZ HOSP,LBI CLIN NEUROBIOL,DEPT NEUROL,VIENNA,AUSTRIA

[3] CHR ANGERS,INSERM,U298,F-49036 ANGERS,FRANCE

来源：

JOURNAL OF NEUROCHEMISTRY | 1990年 / 55卷 / 05期

关键词：

Brain metabolism; Complex I defect; Mitochondrial genome; Parkinson's disease; Respiratory chain;

D O I：

10.1111/j.1471-4159.1990.tb04973.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Abstract: The mitochondrial genome codes for 13 proteins which are located in the respiratory chain. In postmortem brain of patients with Parkinson's disease, decreased activity of complex I of the respiratory chain could be demonstrated. Because seven subunits of complex I are coded by the mitochondrial genome, we analyzed the mitochondrial DNA of human postmortem substantia nigra, putamen, and frontal cortex by the Southern blot technique. No deletions of the mitochondrial genome could be demonstrated, thus indicating that either subunits which are encoded by the nuclear genome are decreased or enzyme activity is diminished by metabolites, toxins, or increase of Fe3+. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：1810 / 1812

页数：3

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