ANIMAL-CELL BIOREACTORS - RECENT ADVANCES AND CHALLENGES TO SCALE-UP

被引：37

作者：

HU, WS

PESHWA, MV

机构：

[1] Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, Minnesota, 55455

来源：

CANADIAN JOURNAL OF CHEMICAL ENGINEERING | 1991年 / 69卷 / 02期

关键词：

ANIMAL CELL CULTURE; BIOREACTOR; SCALE-UP;

D O I：

10.1002/cjce.5450690203

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

The demand for animal cell derived products has stimulated the development of bioreactors in the last decade. Most of those developments allow a higher cell concentration to be achieved in the bioreactor than in the past, primarily by means of the continuous flow of culture medium and a mechanism of cell retention. The advantages and technological challenges of some of these developments are discussed. Lagging behind the bioreactor developments is the strategy for culture operation and optimization. The need for suitable kinetic models to describe animal cell growth is emphasized.

引用

页码：409 / 420

页数：12

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