COLON DISEASES IN THE COTTON-TOP TAMARIN - EVALUATING A PRIMATE MODEL FOR ULCERATIVE-COLITIS AND COLORECTAL-CARCINOMA IN HUMANS

被引：0

作者：

ADAMS, LJ ^{[1
]}

CLAPP, N ^{[1
]}

COLLMANN, IR ^{[1
]}

FUHR, J ^{[1
]}

机构：

[1] UNIV TENNESSEE,MED CTR,MARCOR,OAK RIDGE,TN 37830

来源：

AGENTS AND ACTIONS | 1994年 / 41卷

关键词：

D O I：

10.1007/BF01987654

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Recognition of spontaneous ulcerative colitis in the cotton-top tamarin (CTT) that predisposes the animal to high incidences of colonic carcinoma strongly suggests an animal model that closely parallels these human diseases. This study compares a comprehensive' review of the current literature from researchers associated with three of the largest biomedical research CTT colonies in the world with current observations in humans. The natural history and clinical characteristics of CTT colitis and CTT colonic carcinoma pathogenesis compare remarkably well with the colitis/carcinoma sequence of the human diseases; exceptions are CTT cancer incidences are higher and liver metastases are rare. The immunobiological characteristics are also very similar except that CTT CEA recognition is less consistent, LDH(k) values were inconsistent with cancer diagnosis, and CA-19-9 and Le(x) values were negative in CTTs. Because many similarities exist between the development of colitis and colonic carcinoma in CTTs and humans, the merits of this animal model should be recognized for future colitis and colon cancer research.

引用

页码：C243 / C245

页数：3