SEQUENCE-DEPENDENT BENDING PROPENSITY OF DNA AS REVEALED BY DNASE-I - PARAMETERS FOR TRINUCLEOTIDES

被引：254
|
作者：
BRUKNER, I
SANCHEZ, R
SUCK, D
PONGOR, S
机构：
[1] INT CTR GENET ENGN & BIOTECHNOL,I-34012 TRIESTE,ITALY
[2] EUROPEAN MOLEC BIOL LAB,DIV BIOL STRUCT & BIOCOMP,D-69012 HEIDELBERG,GERMANY
来源：
EMBO JOURNAL | 1995年 / 14卷 / 08期
关键词：
DNA CURVATURE; DNA FLEXIBILITY; DNA-PROTEIN INTERACTION; DNASE I; TRINUCLEOTIDES;
D O I：
10.1002/j.1460-2075.1995.tb07169.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Structural parameters characterizing the bending propensity of trinucleotides were deduced from DNase I digestion data using simple probabilistic models. In contrast to dinucleotide-based models of DNA bending and/or bendability, the trinucleotide parameters are in good agreement with X-ray crystallographic data on bent DNA. This improvement may be due to the fact that the trinucleotide model incorporates more sequence context information than do dinucleotide-based descriptions.
引用
收藏
页码：1812 / 1818
页数：7
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