IDENTIFICATION OF A NEW ADULT HUMAN LIVER SULFOTRANSFERASE WITH SPECIFICITY FOR ENDOGENOUS AND XENOBIOTIC ESTROGENS

被引：44

作者：

FORBESBAMFORTH, KJ ^{[1
]}

COUGHTRIE, MWH ^{[1
]}

机构：

[1] UNIV DUNDEE,NINEWELLS HOSP & MED SCH,DEPT BIOCHEM MED,DUNDEE DD1 9SY,SCOTLAND

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 198卷 / 02期

关键词：

D O I：

10.1006/bbrc.1994.1102

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We present evidence for the existence of a previously undescribed sulfotransferase isoenzyme in adult human liver which sulfates endogenous and xenobiotic estrogens (estrone and 17α-ethinylestradiol). The enzyme was resolved from other sulfotransferases using anion exchange chromatography and further purified by gel filtration and affinity chromatography. Using antibodies against rat liver estrogen and hydroxysteroid sulfotransferases, it was shown that the adult human estrogen sulfotransferase has a subunit molecular weight of 33 kDa, is immunologically related to its rat counterpart and also to the human phenolsulfotransferase enzyme family, but not to human hydroxysteroid sulfotransferase. © 1994 Academic Press, Inc.

引用

页码：707 / 711

页数：5

共 24 条

[1] THE GUT WALL METABOLISM OF ETHINYLESTRADIOL AND ITS CONTRIBUTION TO THE PRE-SYSTEMIC METABOLISM OF ETHINYLESTRADIOL IN HUMANS [J].

BACK, DJ ;

BRECKENRIDGE, AM ;

MACIVER, M ;

ORME, M ;

PURBA, HS ;

ROWE, PH ;

TAYLOR, I .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1982, 13 (03) :325-330

[2] COMMON FOOD-ADDITIVES ARE POTENT INHIBITORS OF HUMAN LIVER 17-ALPHA-ETHINYLESTRADIOL AND DOPAMINE SULFOTRANSFERASES [J].

BAMFORTH, KJ ;

JONES, AL ;

ROBERTS, RC ;

COUGHTRIE, MWH .

BIOCHEMICAL PHARMACOLOGY, 1993, 46 (10) :1713-1720

[3] INHIBITION OF HUMAN LIVER STEROID SULFOTRANSFERASE ACTIVITIES BY DRUGS - A NOVEL MECHANISM OF DRUG TOXICITY [J].

BAMFORTH, KJ ;

DALGLIESH, K ;

COUGHTRIE, MWH .

EUROPEAN JOURNAL OF PHARMACOLOGY-ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY SECTION, 1992, 228 (01) :15-21

[4] PURIFICATION AND IMMUNOCHEMICAL CHARACTERIZATION OF A MALE-SPECIFIC RAT-LIVER ESTROGEN SULFOTRANSFERASE [J].

BORTHWICK, EB ;

BURCHELL, A ;

COUGHTRIE, MWH .

BIOCHEMICAL JOURNAL, 1993, 289 :719-725

[5] PURIFICATION AND IMMUNOCHEMICAL CHARACTERIZATION OF A RAT-LIVER SULFOTRANSFERASE CONJUGATING PARACETAMOL [J].

COUGHTRIE, MWH ;

SHARP, S .

BIOCHEMICAL PHARMACOLOGY, 1990, 40 (10) :2305-2313

[6] ESTROGEN SULFOTRANSFERASE OF THE RAT-LIVER - COMPLEMENTARY-DNA CLONING AND AGE-SPECIFIC AND SEX-SPECIFIC REGULATION OF MESSENGER-RNA [J].

DEMYAN, WF ;

SONG, CS ;

KIM, DS ;

HER, S ;

GALLWITZ, W ;

RAO, TR ;

SLOMCZYNSKA, M ;

CHATTERJEE, B ;

ROY, AK .

MOLECULAR ENDOCRINOLOGY, 1992, 6 (04) :589-597

[7] MOLECULAR ENZYMOLOGY OF HUMAN LIVER CYTOSOLIC SULFOTRANSFERASES [J].

FALANY, CN .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1991, 12 (07) :255-259

[8] PURIFICATION AND CHARACTERIZATION OF HUMAN LIVER PHENOL-SULFATING PHENOL SULFOTRANSFERASE [J].

FALANY, CN ;

VAZQUEZ, ME ;

HEROUX, JA ;

ROTH, JA .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1990, 278 (02) :312-318

[9] PURIFICATION AND CHARACTERIZATION OF HUMAN-LIVER DEHYDROEPIANDROSTERONE SULFOTRANSFERASE [J].

FALANY, CN ;

VAZQUEZ, ME ;

KALB, JM .

BIOCHEMICAL JOURNAL, 1989, 260 (03) :641-646

[10]

HERNANDEZ JS, 1992, DRUG METAB DISPOS, V20, P413

← 1 2 3 →