IDENTIFICATION OF A NEW ADULT HUMAN LIVER SULFOTRANSFERASE WITH SPECIFICITY FOR ENDOGENOUS AND XENOBIOTIC ESTROGENS

被引：44
作者：
FORBESBAMFORTH, KJ [1 ]
COUGHTRIE, MWH [1 ]
机构：
[1] UNIV DUNDEE,NINEWELLS HOSP & MED SCH,DEPT BIOCHEM MED,DUNDEE DD1 9SY,SCOTLAND
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 198卷 / 02期
关键词：
D O I：
10.1006/bbrc.1994.1102
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We present evidence for the existence of a previously undescribed sulfotransferase isoenzyme in adult human liver which sulfates endogenous and xenobiotic estrogens (estrone and 17α-ethinylestradiol). The enzyme was resolved from other sulfotransferases using anion exchange chromatography and further purified by gel filtration and affinity chromatography. Using antibodies against rat liver estrogen and hydroxysteroid sulfotransferases, it was shown that the adult human estrogen sulfotransferase has a subunit molecular weight of 33 kDa, is immunologically related to its rat counterpart and also to the human phenolsulfotransferase enzyme family, but not to human hydroxysteroid sulfotransferase. © 1994 Academic Press, Inc.
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页码：707 / 711
页数：5
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