EVALUATION OF A MULTICENTER STUDY WITH IOMAZENIL - A BENZODIAZEPINE RECEPTOR LIGAND

被引：56

作者：

SCHUBIGER, PA

HASLER, PH

BEERWOHLFAHRT, H

BEKIER, A

OETTLI, R

CORDES, M

FERSTL, F

DEISENHAMMER, E

DEROO, M

MOSER, E

NITZSCHE, E

PODREKA, I

RICCABONA, G

BANGERL, I

SCHOBER, O

BARTENSTEIN, P

VANRIJK, P

VANISSELT, JW

VANROYEN, EA

VERHOEFF, NPLG

HALDEMANN, R

VONSCHULTHESS, GK

机构：

[1] Radiopharmacy Division, Paul Scherrer Institute, Villigen, PSI

[2] Institut für Nuklearmedizin, Kantonsspital, St Gallen

[3] Nuklearmedizin, Universitätsklinikum Charlottenburg, Berlin 19

[4] Neuro-Nuklearmedizin, Wagner-jauregg Hospital, Linz

[5] Dienst Nucleaire Geneeskunde, U.Z. Gasthuisberg, Leuven

[6] Nuklearmedizin, Klinikum der Albert-Ludwigs-Universität, Freiburg/Br

[7] Neurologische Universitätsklinik, Vienna

[8] Universitätsklinik für Nuklearmedizin, Innsbruck

[9] Klinik für Nuklearmedizin, Westfälische Wilhelms-Universität, Munster

[10] Academisch Ziekenhuis, Utrecht

[11] Afd. Nucleaire Geneeskunde, Academisch Medisch Centrum, Amsterdam, AZ

[12] Klinik und Polyklinik für Nuklearmedizin, Universitätsspital, Zurich

来源：

NUCLEAR MEDICINE COMMUNICATIONS | 1991年 / 12卷 / 07期

关键词：

D O I：

10.1097/00006231-199107000-00002

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

After showing in an earlier publication that Iomazenil is a potent benzodiazepine receptor antagonist, the substance has been distributed to 11 clinical centres in Europe for further tests. The protocol asked for volunteers, epileptic cases and patients with Alzheimer's disease. Prior to the Iomazenil examination, flow images by perfusamine or HMPAO were required, and as comparative methods EEG, computed tomography (CT) and magnetic resonance imaging (MRI) were performed. The results allowed first the determination of the normal distribution of the benzodiazepine receptors in the human brain. The highest uptake was found in medial occipital cortex. Second, the evaluation of the epileptic cases shows a 100% positive prediction value for Iomazenil compared to 92% for flow images. Negative prediction values were calculated as 81% for Iomazenil and 54% for flow images. Furthermore, one group reported the successful diagnosis of Alzheimer's disease at an early stage. The visual image examination was tentatively compared to a more objective semiquantitative one based on quotients of corresponding left/right regions of interest. This semiquantitative method has not proved successful yet, but the problems have been identified. A more precise protocol for further studies is therefore proposed.

引用

页码：569 / 582

页数：14

共 16 条

[1]

Beer H.F., Blauenstein P.A., Hasler P.H., Delaloye B., Riccabona G., Bangerl I., Hunkeler W., Bonetti E.P., Pieri L., Richards J.G., Schubiger P.A., In vitro and in vivo evaluation of iodine-123- Ro 16-0154: A new imaging agent for SPECT investigations of benzodiazepine receptors, J Nucl Med, 31, pp. 1007-1014, (1990)

[2]

Holl K., Deisenhammer E., Dauth J., Carmann H., Schubiger P.A., Imaging benzodiazepine receptors in the human brain by single photon emission computed tomography (SPECT), Nucl Med Biol, 16, pp. 759-763, (1989)

[3]

Bangerl I., Riccabona G., Bauer G., Bohr K., Hasler P.H., Schubiger P.A., 123I-Iomazenil brain SPECT in various forms of epilepsy (A preliminary report), Nuclear Medicine, pp. 325-327, (1990)

[4]

Bartenstein P., Ludolph A., Schober O., Lottes G., Bottger I., Beer H.F., Vergleich von Blutfluss und Benzodiazepin-Rezeptorverteilung bei fokaler Epilepsie: Vorlaufige Ergebnisse einer SPECT-Studie, Nucl Med, 28, pp. 181-186, (1989)

[5]

Verhoeff N., Van Royen E.A., Overweg J., Limburg M., Hijdra A., Linszen D., Benzodiazepine receptor density in human brain measured in vivo with123I-Iomazenil SPECT, Eur J Nucl Med, 16, (1990)

[6]

Haldemann R., Schubiger P.A., Von Schulthess G.K., Darstellung der Benzodiazepinerezep- toren des Gehirns mit I-123-Iomazenil, Picker Aktuell, 12, pp. 13-18, (1989)

[7]

Verhoeff N., Van Royen E.A., Overweg J., Limburg M., Hijdra A., Linszen D., 123I- Iomazenil whole body distribution in human volunteers, Eur J Nucl Med, 16, (1990)

[8]

Verhoeff N., Van Royen E.A., Overweg J., Limburg M., Hijdra A., Linszen D., 123I- Iomazenil dynamic whole brain activity in human volunteers, Eur J Nucl Med, 16, (1990)

[9]

Nitzsche E., Landwehrmeyer B., Moser E., Lucking C.H., Ott D., Hasler P.H., Schubiger P.A., Hirn-SPECT mit Tc-99m-HM-PAO und I-123-Iomazenil bei Patienten mit fokaler Epilepsie und Morbus Alzheimer's disease, Iomazenil and Other Brain Receptor Tracers for SPECT, Proceedings of the 6Th Böttstein Colloquium Held at Würenlingen/Villigen, pp. 65-70, (1990)

[10]

Pieniadz I.M., Naeser M.A., Koff E., Levine H., Scan cerebral hemisphere asymmetry measurements in stroke cases with global aphasia, Atypical Asymmetries Associated with Improved Recovery. Cortex, 19, pp. 371-391, (1983)

← 1 2 →