INVITRO REPLICATION THROUGH NUCLEOSOMES WITHOUT HISTONE DISPLACEMENT

被引：114
作者：
BONNEANDREA, C [1 ]
WONG, ML [1 ]
ALBERTS, BM [1 ]
机构：
[1] UNIV CALIF SAN FRANCISCO,DEPT BIOCHEM & BIOPHYS,SAN FRANCISCO,CA 94143
来源：
NATURE | 1990年 / 343卷 / 6260期
关键词：
D O I：
10.1038/343719a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A well-characterized set of proteins encoded by bacteriophage T4 replicates DNA in vitro and generates replication forks that can pass nucleo-somes. The histone octamers remain associated with newly replicated DNA even in the presence of excess DNA competitor, and intact nucleosomes re-form on the two daughter DNA helices. It is concluded that nucleosomes are designed to open up transiently to allow the passage of a replication fork without histone displacement. © 1990 Nature Publishing Group.
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页码：719 / 726
页数：8
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