THE EFFECT OF N-ALKYLATION ON THE GAS-PHASE BASICITIES OF SMALL PEPTIDES MEASURED BY THE KINETIC METHOD

被引:11
作者
KALTASHOV, IA [1 ]
FENSELAU, CC [1 ]
机构
[1] UNIV MARYLAND,DEPT CHEM & BIOCHEM,BALTIMORE,MD 21228
来源
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY AND ION PROCESSES | 1995年 / 146卷
基金
美国国家科学基金会;
关键词
BIOMOLECULES; COMPUTER SIMULATIONS; GAS PHASE BASICITIES; KINETIC METHOD; METASTABLE IONS;
D O I
10.1016/0168-1176(95)04196-R
中图分类号
O64 [物理化学(理论化学)、化学物理学]; O56 [分子物理学、原子物理学];
学科分类号
070203 ; 070304 ; 081704 ; 1406 ;
摘要
Gas phase basicities for a series of N-alkylated peptides were found by the kinetic method using amines and guanidines as reference bases. The basicity value of one of these peptides was then remeasured using the rest of the derivatized peptides as reference bases. Both values appear to be in a good agreement. This suggests that structurally similar peptides (with unaltered topology of intramolecular hydrogen bonding) can be used as reference bases in the kinetic method experiments.
引用
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页码:339 / 347
页数:9
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