A SUCCESSFUL MURINE MODEL FOR CONTACT SENSITIZATION TO A SESQUITERPENE-ALPHA-METHYLENE-GAMMA-BUTYROLACTONE - SENSITIZATION TO ALANTOLACTONE IN 4 STRAINS OF MICE

被引：4
作者：
FRAGINALS, R
BLASI, NA
LEPOITTEVIN, JP
BENEZRA, C
机构：
[1] UNIV CADIZ,FAC MED,CADIZ,SPAIN
[2] UNIV STRASBOURG 1,INST HEMATOL & IMMUNOL,F-67070 STRASBOURG,FRANCE
来源：
JOURNAL OF INVESTIGATIVE DERMATOLOGY | 1991年 / 97卷 / 03期
关键词：
D O I：
10.1111/1523-1747.ep12481500
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Induction of allergic contact hypersensitivity to a sesquiterpene lactone, alantolactone, was studied in four strains of mice: C3H/He, DBA/2, Balb/b, and Balb/c. The last three were successfully sensitized. A significant dose/response was demonstrated in these species, as well as an experimental "overload effect" in Balb/c and Balb/b strains. Histologic studies confirmed the allergic nature of the reaction. From the overall results, alantolactone can be considered a moderate sensitizer in mouse as well as in guinea pig. This study shows that the murine model can be used for experimental contact sensitization with moderate allergens, without the use of Freund's adjuvant for induction.
引用
收藏
页码：473 / 477
页数：5
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