INDUCTION OF DNA DOUBLE STRAND BREAKS IN CULTURED-MAMMALIAN-CELLS EXPOSED TO HYDROGEN-PEROXIDE AND HISTIDINE

被引：3

作者：

CANTONI, O

SESTILI, P

CATTABENI, F

机构：

[1] Istituto di Farmacologia e Farmacognosia and Centro di Farmacologia Oncologica Sperimentale, Università di Urbino, Urbino, 61029, Via S. Chiara

来源：

CYTOTECHNOLOGY | 1991年 / 5卷

关键词：

D O I：

10.1007/BF00736816

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The amino acid histidine was found to increase the toxicity of H2O2 in cultured mammalian cells. Histidine also augmented the level of DNA single strand breaks (SSB) detectable in cells exposed to the oxidant and, in addition, resulted in the appearance of DNA double strand breaks (DSB), a lesion which is not produced by H2O2 alone.

引用

页码：80 / 81

页数：2

共 7 条

[1]

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[2]

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[7]

Cantoni O., Murray D., Cattabeni F., Stocchi V., Cerutti P., Meyn R.E., Hydrogen peroxide insult in cultured mammalian cells: relationships between DNA single-strand breakage, poly(ADP)-ribosylation, and cell killing, Biochim. Biophys. Acta, 1014, pp. 1-7, (1989)

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