Synthesis and evaluation of antiviral, antitubercular and anticancer activities of some novel thioureas derived from 4-aminobenzohydrazide hydrazones

被引：31

作者：

Cikla, Pelin ^{[1
]}

Kucukguzel, S. Guniz ^{[1
]}

Kucukguzel, Ilkay ^{[1
]}

Rollas, Sevim ^{[1
]}

De Clercq, Erik ^{[2
]}

Pannecouque, Christophe ^{[2
]}

Andrei, Graciela ^{[2
]}

Snoeck, Robert ^{[2
]}

Sahin, Fikrettin ^{[3
]}

Bayrak, Omer Faruk ^{[3
]}

机构：

[1] Marmara Univ, Fac Pharm, Dept Pharmaceut Chem, Istanbul, Turkey

[2] Katholieke Univ Leuven, Rega Inst Med Res, Leuven, Belgium

[3] Yeditepe Univ, Fac Engn & Architecture, Genet & Bioengn Dept, Istanbul, Turkey

来源：

MARMARA PHARMACEUTICAL JOURNAL | 2010年 / 14卷 / 01期

关键词：

Hydrazones; Thioureas; Antiviral activity; Anticancer activity; Mycobacterium tuberculosis H37Rv;

D O I：

10.12991/201014460

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A series of novel 1-[4-[[2-[(4-substituted phenyl) methylene] hydrazino] carbonyl] p henyl]-3-substituted thiourea derivatives have been synthesized by the addition of substituted aryl isothiocyanates to 4-amino-N'-[(4-substituted phenyl) methylene] benzohydrazide, which was prepared by condensation of 4-aminobenzoic acid hydrazide with 4-fluorobenzaldehyde or 4-(trifluoromethyl) benzaldeyde. All synthesized compounds were evaluated in vitro against HIV-1 (IIIB) and HIV-2 (ROD) strains in MT-4 cells, as well as other selected viruses such as HSV-1, HSV-2, Coxsackie virus B4, Sindbis virus, human cytomegalovirus, and varicella-zoster virus using HeLa, Vero, or HEL cell cultures. Antimycobacterial activity against Mycobacterium tuberculosis H37 Rv was also evaluated. The anticancer activity and cytotoxicity screening of the synthesized compounds were determined on A 549 and L 929 cell lines.

引用

页码：13 / 20

页数：8

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