THE LEADER POLYPEPTIDE OF THEILERS VIRUS IS ESSENTIAL FOR NEUROVIRULENCE BUT NOT FOR VIRUS GROWTH IN BHK CELLS

被引：28

作者：

CALENOFF, MA

BADSHAH, CS

DALCANTO, MC

LIPTON, HL

RUNDELL, MK

机构：

[1] NORTHWESTERN UNIV,SCH MED,DEPT MICROBIOL IMMUNOL,CHICAGO,IL 60611

[2] NORTHWESTERN UNIV,SCH MED,DEPT PATHOL,CHICAGO,IL 60611

[3] EVANSTON HOSP CORP,DEPT NEUROL,EVANSTON,IL 60201

来源：

JOURNAL OF VIROLOGY | 1995年 / 69卷 / 09期

关键词：

D O I：

10.1128/JVI.69.9.5544-5549.1995

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A leader polypeptide of unknown function is encoded by cardioviruses, such as Theiler's murine encephalomyelitis virus. Although the deletion of this polypeptide has little effect on the growth of parental GDVII virus in baby hamster kidney (BHK) cells, the mutant virus is completely attenuated and fails to kill mice receiving intracerebral inoculations of high doses of the virus.

引用

页码：5544 / 5549

页数：6

共 36 条

[1] BADSHAH C, UNPUB
[2] SIMULTANEOUS INSITU DETECTION OF VIRAL-RNA AND ANTIGENS
BRAHIC, M
HAASE, AT
CASH, E
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (17): : 5445 - 5448
[3] GENOMIC REGIONS OF NEUROVIRULENCE AND ATTENUATION IN THEILER MURINE ENCEPHALOMYELITIS VIRUS
CALENOFF, MA
FAABERG, KS
LIPTON, HL
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (03) : 978 - 982
[4] SINGLE-STEP METHOD OF RNA ISOLATION BY ACID GUANIDINIUM THIOCYANATE PHENOL CHLOROFORM EXTRACTION
CHOMCZYNSKI, P
SACCHI, N
[J]. ANALYTICAL BIOCHEMISTRY, 1987, 162 (01) : 156 - 159
[5] CLASS-II-RESTRICTED T-CELL RESPONSES IN THEILERS MURINE ENCEPHALOMYELITIS VIRUS (TMEV)-INDUCED DEMYELINATING DISEASE .2. SURVEY OF HOST IMMUNE-RESPONSES AND CENTRAL-NERVOUS-SYSTEM VIRUS TITERS IN INBRED MOUSE STRAINS
CLATCH, RJ
LIPTON, HL
MILLER, SD
[J]. MICROBIAL PATHOGENESIS, 1987, 3 (05) : 327 - 337
[6] LEADER PROTEIN OF FOOT-AND-MOUTH-DISEASE VIRUS IS REQUIRED FOR CLEAVAGE OF THE P220 COMPONENT OF THE CAP-BINDING PROTEIN COMPLEX
DEVANEY, MA
VAKHARIA, VN
LLOYD, RE
EHRENFELD, E
GRUBMAN, MJ
[J]. JOURNAL OF VIROLOGY, 1988, 62 (11) : 4407 - 4409
[7] REPLICATION OF THEILERS MURINE ENCEPHALOMYELITIS VIRUSES IN BHK-21-CELLS - ELECTRON-MICROSCOPIC STUDY
FRIEDMANN, A
LIPTON, HL
[J]. VIROLOGY, 1980, 101 (02) : 389 - 398
[8] NEUROVIRULENCE DETERMINANTS OF GENETICALLY ENGINEERED THEILER VIRUSES
FU, JL
STEIN, S
ROSENSTEIN, L
BODWELL, T
ROUTBORT, M
SEMLER, BL
ROOS, RP
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (11) : 4125 - 4129
[9] STRAINS FROM BOTH THEILERS VIRUS SUBGROUPS ENCODE A DETERMINANT FOR DEMYELINATION
FU, JL
RODRIGUEZ, M
ROOS, RP
[J]. JOURNAL OF VIROLOGY, 1990, 64 (12) : 6345 - 6348
[10] GERETY SJ, 1994, J IMMUNOL, V152, P908

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