THE TREATMENT OF HEART-FAILURE - WHAT NEXT

被引：2
作者：
DAVIES, RH [1 ]
SHERIDAN, DJ [1 ]
机构：
[1] ST MARYS HOSP, DEPT ACAD CARDIOL, LONDON W2 1NY, ENGLAND
来源：
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1993年 / 35卷 / 06期
关键词：
HEART FAILURE; MEDICAL THERAPY;
D O I：
10.1111/j.1365-2125.1993.tb04181.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1 Despite demonstrable benefits in terms of symptomatic relief and improvement in prognosis, even the best treatments of heart failure currently available fall short of being ideal. We review the basis for newer approaches to the treatment of heart failure and discuss some of the agents which capitalize on current understanding of the underlying patho-physiology. 2 Several drugs, old and new, are presently being investigated by major clinical trials. We also consider some of the difficulties related to the design and conduct of such trials and suggest how drugs might be better assessed in the future.
引用
收藏
页码：557 / 563
页数：7
相关论文
共 95 条
[1]  
ADAMS KF, 1992, CIRCULATION, V86, P377
[2]   LONG-TERM (2-YEAR) BENEFICIAL-EFFECTS OF BETA-ADRENERGIC-BLOCKADE WITH BUCINDOLOL IN PATIENTS WITH IDIOPATHIC DILATED CARDIOMYOPATHY [J].
ANDERSON, JL ;
GILBERT, EM ;
OCONNELL, JB ;
RENLUND, D ;
YANOWITZ, F ;
MURRAY, M ;
ROSKELLEY, M ;
MEALEY, P ;
VOLKMAN, K ;
DEITCHMAN, D ;
BRISTOW, M .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1991, 17 (06) :1373-1381
[3]   INOTROPIC EFFECT OF NICARDIPINE IN PATIENTS WITH HEART-FAILURE - ASSESSMENT BY LEFT-VENTRICULAR END-SYSTOLIC PRESSURE-VOLUME ANALYSIS [J].
ARONEY, CN ;
SEMIGRAN, MJ ;
DEC, GW ;
BOUCHER, CA ;
FIFER, MA .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1989, 14 (05) :1331-1338
[4]   REVERSION OF CARDIAC-HYPERTROPHY AND REDUCED ARTERIAL COMPLIANCE AFTER CONVERTING ENZYME-INHIBITION IN ESSENTIAL-HYPERTENSION [J].
ASMAR, RG ;
PANNIER, B ;
SANTONI, JP ;
LAURENT, S ;
LONDON, GM ;
LEVY, BI ;
SAFAR, ME .
CIRCULATION, 1988, 78 (04) :941-950
[5]   INFLUENCE OF POSITIVE INOTROPIC THERAPY ON PULSATILE HYDRAULIC LOAD AND VENTRICULAR-VASCULAR COUPLING IN CONGESTIVE HEART-FAILURE [J].
BINKLEY, PF ;
VANFOSSEN, DB ;
NUNZIATA, E ;
UNVERFERTH, DV ;
LEIER, CV .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1990, 15 (05) :1127-1135
[6]  
BINKLEY PF, 1992, J AM COLL CARDIOL, V19, P1121
[7]   DECREASED CATECHOLAMINE SENSITIVITY AND BETA-ADRENERGIC-RECEPTOR DENSITY IN FAILING HUMAN HEARTS [J].
BRISTOW, MR ;
GINSBURG, R ;
MINOBE, W ;
CUBICCIOTTI, RS ;
SAGEMAN, WS ;
LURIE, K ;
BILLINGHAM, ME ;
HARRISON, DC ;
STINSON, EB .
NEW ENGLAND JOURNAL OF MEDICINE, 1982, 307 (04) :205-211
[8]   PHYSIOLOGY AND PHARMACOLOGY OF CARDIOVASCULAR CATECHOLAMINE RECEPTORS - IMPLICATIONS FOR TREATMENT OF CHRONIC HEART-FAILURE [J].
BRODDE, OE .
AMERICAN HEART JOURNAL, 1990, 120 (06) :1565-1572
[9]   RENIN RELATIONSHIPS IN CONGESTIVE CARDIAC FAILURE, TREATED AND UNTREATED [J].
BROWN, JJ ;
DAVIES, DL ;
JOHNSON, VW ;
LEVER, AF ;
ROBERTSON, JI .
AMERICAN HEART JOURNAL, 1970, 80 (03) :329-+
[10]   POSITIVE INOTROPIC AND LUSITROPIC EFFECTS OF INTRAVENOUS FLOSEQUINAN IN PATIENTS WITH HEART-FAILURE [J].
BURSTEIN, S ;
SEMIGRAN, MJ ;
DEC, GW ;
BOUCHER, CA ;
FIFER, MA .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1992, 20 (04) :822-829
12345678910