GLUCOSE, LACTIC-ACID, AND PERINATAL HYPOXIC-ISCHEMIC BRAIN-DAMAGE

被引：68
作者：
VANNUCCI, RC
YAGER, JY
机构：
[1] Division of Pediatric Neurology, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, PA
来源：
PEDIATRIC NEUROLOGY | 1992年 / 8卷 / 01期
关键词：
D O I：
10.1016/0887-8994(92)90045-Z
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Investigations suggest that hyperglycemia, superimposed on hypoxia-ischemia or cerebral ischemia, accentuates brain damage in adult experimental animals and humans, but not in immature animals. Fundamental differences in the immature and adult brain, which account for the age-specific paradox, are discussed. Based on currently available data, we recommend that glucose supplementation not be curtailed during labor and delivery of asphyxiated human infants; on the contrary, glucose therapy may substantially reduce hypoxic-ischemic brain damage.
引用
收藏
页码：3 / 12
页数：10
相关论文
共 91 条
[61]   INCREASED DAMAGE AFTER ISCHEMIC STROKE IN PATIENTS WITH HYPERGLYCEMIA WITH OR WITHOUT ESTABLISHED DIABETES-MELLITUS [J].
PULSINELLI, WA ;
LEVY, DE ;
SIGSBEE, B ;
SCHERER, P ;
PLUM, F .
AMERICAN JOURNAL OF MEDICINE, 1983, 74 (04) :540-544
[62]   MODERATE HYPERGLYCEMIA AUGMENTS ISCHEMIC BRAIN-DAMAGE - A NEUROPATHOLOGIC STUDY IN THE RAT [J].
PULSINELLI, WA ;
WALDMAN, S ;
RAWLINSON, D ;
PLUM, F .
NEUROLOGY, 1982, 32 (11) :1239-1246
[63]   BRAIN LACTIC-ACIDOSIS AND ISCHEMIC CELL-DAMAGE .1. BIOCHEMISTRY AND NEUROPHYSIOLOGY [J].
REHNCRONA, S ;
ROSEN, I ;
SIESJO, BK .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1981, 1 (03) :297-311
[64]   EXCESSIVE CELLULAR ACIDOSIS - AN IMPORTANT MECHANISM OF NEURONAL DAMAGE IN THE BRAIN [J].
REHNCRONA, S ;
ROSEN, I ;
SIESJO, BK .
ACTA PHYSIOLOGICA SCANDINAVICA, 1980, 110 (04) :435-437
[65]   THE INFLUENCE OF IMMATURITY ON HYPOXIC-ISCHEMIC BRAIN-DAMAGE IN THE RAT [J].
RICE, JE ;
VANNUCCI, RC ;
BRIERLEY, JB .
ANNALS OF NEUROLOGY, 1981, 9 (02) :131-141
[66]  
RORKE LB, 1982, PATHOLOGY PERINATAL, P4
[67]   OUTCOME OF VERY SEVERE BIRTH ASPHYXIA [J].
SCOTT, H .
ARCHIVES OF DISEASE IN CHILDHOOD, 1976, 51 (09) :712-716
[68]   CEREBRAL BLOOD-FLOW AND EXCHANGE OF OXYGEN, GLUCOSE KETONE-BODIES, LACTATE, PYRUVATE AND AMINO-ACIDS IN ANESTHETIZED CHILDREN [J].
SETTERGREN, G ;
LINDBLAD, BS ;
PERSSON, B .
ACTA PAEDIATRICA SCANDINAVICA, 1980, 69 (04) :457-465
[69]   REMOVAL AND UTILIZATION OF KETONE BODIES BY BRAIN OF NEWBORN PUPPIES [J].
SPITZER, JJ ;
WENG, JT .
JOURNAL OF NEUROCHEMISTRY, 1972, 19 (09) :2169-&
[70]   THE SURVIVAL OF YOUNG RATS IN NITROGEN [J].
STAFFORD, A ;
WEATHERALL, JAC .
JOURNAL OF PHYSIOLOGY-LONDON, 1960, 153 (03) :457-472
12345678910