GLUCOSE, LACTIC-ACID, AND PERINATAL HYPOXIC-ISCHEMIC BRAIN-DAMAGE

被引：68
作者：
VANNUCCI, RC
YAGER, JY
机构：
[1] Division of Pediatric Neurology, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, PA
来源：
PEDIATRIC NEUROLOGY | 1992年 / 8卷 / 01期
关键词：
D O I：
10.1016/0887-8994(92)90045-Z
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Investigations suggest that hyperglycemia, superimposed on hypoxia-ischemia or cerebral ischemia, accentuates brain damage in adult experimental animals and humans, but not in immature animals. Fundamental differences in the immature and adult brain, which account for the age-specific paradox, are discussed. Based on currently available data, we recommend that glucose supplementation not be curtailed during labor and delivery of asphyxiated human infants; on the contrary, glucose therapy may substantially reduce hypoxic-ischemic brain damage.
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页码：3 / 12
页数：10
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